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Title: Transcriptional enhancer from milk protein genes

Abstract

The invention relates to novel enhancer nucleotide sequences which stimulate transcription of heterologous DNA in cells in culture. The enhancers are derived from major milk protein genes by the process of deletion mapping and functional analysis. The invention also relates to expression vectors containing the novel enhancers.

Inventors:
 [1];  [2];  [2]
  1. Ballwin, MO
  2. Berkeley, CA
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
872774
Patent Number(s):
6004805
Assignee:
G.D Searle & Co. (Chicago, IL)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
transcriptional; enhancer; milk; protein; genes; relates; novel; nucleotide; sequences; stimulate; transcription; heterologous; dna; cells; culture; enhancers; derived; major; process; deletion; mapping; functional; analysis; expression; vectors; containing; nucleotide sequences; nucleotide sequence; expression vectors; protein genes; milk protein; expression vector; /435/999/

Citation Formats

Casperson, Gerald F, Schmidhauser, Christian T, and Bissell, Mina J. Transcriptional enhancer from milk protein genes. United States: N. p., 1999. Web.
Casperson, Gerald F, Schmidhauser, Christian T, & Bissell, Mina J. Transcriptional enhancer from milk protein genes. United States.
Casperson, Gerald F, Schmidhauser, Christian T, and Bissell, Mina J. Fri . "Transcriptional enhancer from milk protein genes". United States. https://www.osti.gov/servlets/purl/872774.
@article{osti_872774,
title = {Transcriptional enhancer from milk protein genes},
author = {Casperson, Gerald F and Schmidhauser, Christian T and Bissell, Mina J},
abstractNote = {The invention relates to novel enhancer nucleotide sequences which stimulate transcription of heterologous DNA in cells in culture. The enhancers are derived from major milk protein genes by the process of deletion mapping and functional analysis. The invention also relates to expression vectors containing the novel enhancers.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

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Works referenced in this record:

Rabbit β-Casein Promoter Directs Secretion of Human Interleukin-2 into the Milk of Transgenic Rabbits
journal, February 1990


A novel transcriptional enhancer is involved in the prolactin- and extracellular matrix-dependent regulation of beta-casein gene expression.
journal, June 1992


Extracellular matrix and hormones transcriptionally regulate bovine beta-casein 5' sequences in stably transfected mouse mammary cells.
journal, December 1990


Relative Contribution of Promoter and Intragenic Sequences in the Hormonal Regulation of Rat β-Casein Transgenes
journal, March 1989


Differential regulation of rat beta-casein-chloramphenicol acetyltransferase fusion gene expression in transgenic mice.
journal, February 1989


Prolactin stimulates milk protein promoter in CHO cells cotransfected with prolactin receptor cDNA
journal, May 1990


Gene Transfer into Sheep
journal, February 1988


Production of Human Tissue Plasminogen Activator in Transgenic Mouse Milk
journal, November 1987


High Level Expression of Active Human Alpha-1-Antitrypsin in the Milk of Transgenic Sheep
journal, September 1991


Prolactin and Glucocorticoid Hormones Control Transcription of the β-Casein Gene by Kinetically Distinct Mechanisms
journal, June 1990


Hormonal response region in the mouse mammary tumor virus long terminal repeat can be dissociated from the proviral promoter and has enhancer properties.
journal, February 1985


Lactogenic Hormone and Cell Type-Specific Control of the Whey Acidic Protein Gene Promoter in Transfected Mouse Cells
journal, November 1991


Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice.
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Developmental and environmental regulation of a mammary gland-specific nuclear factor essential for transcription of the gene encoding beta-casein.
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Transfection of beta-casein chimeric gene and hormonal induction of its expression in primary murine mammary epithelial cells.
journal, May 1990


High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region.
journal, March 1992


Expression of Human Anti-Hemophilic Factor IX in the Milk of Transgenic Sheep
journal, May 1989


Bovine AlphaS1-Casein Gene Sequences Direct High Level Expression of Active Human Urokinase in Mouse Milk
journal, May 1990


High-level expression of biologically active human alpha 1-antitrypsin in the milk of transgenic mice.
journal, July 1990


Expression of biologically active heterodimeric bovine follicle-stimulating hormone in milk of transgenic mice.
journal, October 1991


A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice.
journal, August 1988