Title: Combinatorial synthesis of novel materials

Abstract

Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties.

Inventors:

Schultz, Peter G ^[1]; Xiang, Xiaodong ^[2]; Goldwasser, Isy ^[3]

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+ Show Inventor Affiliations

1. Oakland, CA
2. Alameda, CA
3. Menlo Park, CA

Issue Date:

1999-01-01

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

OSTI Identifier:

872771

Patent Number(s):

6004617

Application Number:

08/480007

Assignee:

Regents of University of California (Oakland, CA); Symyx Technologies (Santa Clara, CA)

Patent Classifications (CPCs):

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

B01J19/0046 - {Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides
B01J2219/00313 - the reactor vessels being formed by arrays of wells in blocks
B01J2219/00317 - Microwell devices, i.e. having large numbers of wells
B01J2219/00378 - Piezo-electric or ink jet dispensers
B01J2219/0043 - for direct application of reagents, e.g. through openings in a shutter
B01J2219/00432 - Photolithographic masks
B01J2219/00436 - Maskless processes
B01J2219/00441 - using lasers
B01J2219/00443 - Thin film deposition
B01J2219/00475 - Sheets
B01J2219/005 - Beads
B01J2219/00511 - Walls of reactor vessels
B01J2219/00515 - in the shape of strings
B01J2219/0052 - in the shape of elongated tubes
B01J2219/00527 - Sheets
B01J2219/00531 - essentially square
B01J2219/00533 - essentially rectangular
B01J2219/00536 - in the shape of disks
B01J2219/0054 - Means for coding or tagging the apparatus or the reagents
B01J2219/00585 - Parallel processes
B01J2219/0059 - Sequential processes
B01J2219/00592 - Split-and-pool, mix-and-divide processes
B01J2219/00596 - Solid-phase processes
B01J2219/00605 - the compounds being directly bound or immobilised to solid supports
B01J2219/0061 - The surface being organic
B01J2219/00612 - the surface being inorganic
B01J2219/0063 - Other, e.g. van der Waals forces, hydrogen bonding
B01J2219/00637 - by coating it with another layer
B01J2219/00646 - the compounds being bound to beads immobilised on the solid supports
B01J2219/00648 - by the use of solid beads
B01J2219/00659 - Two-dimensional arrays
B01J2219/00689 - using computers
B01J2219/00691 - using robots
B01J2219/00711 - Light-directed synthesis
B01J2219/0072 - Organic compounds
B01J2219/00745 - Inorganic compounds
B01J2219/00747 - Catalysts
B01J2219/00752 - Alloys
B01J2219/00754 - Metal oxides

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

B82Y25/00 - Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
B82Y30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

C - CHEMISTRY C01 - INORGANIC CHEMISTRY C01G - COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F

C01G51/68 - {containing rare earth, e.g. La0.3Sr0.7CoO3}

C - CHEMISTRY C01 - INORGANIC CHEMISTRY C01P - INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS

C01P2002/34 - perovskite-type
C01P2002/72 - by d-values or two theta-values, e.g. as X-ray diagram
C01P2002/77 - by unit-cell parameters, atom positions or structure diagrams
C01P2004/84 - one phase coated with the other
C01P2006/40 - Electric properties
C01P2006/42 - Magnetic properties

C - CHEMISTRY C04 - CEMENTS C04B - LIME, MAGNESIA

C04B35/01 - based on oxide ceramics
C04B35/62218 - {obtaining ceramic films, e.g. by using temporary supports}

C - CHEMISTRY C23 - COATING METALLIC MATERIAL C23C - COATING METALLIC MATERIAL

C23C14/042 - {using masks}
C23C14/087 - {of copper or solid solutions thereof}
C23C16/042 - {using masks}

C - CHEMISTRY C40 - COMBINATORIAL TECHNOLOGY C40B - COMBINATORIAL CHEMISTRY

C40B30/08 - by measuring catalytic activity
C40B40/18 - Libraries containing only inorganic compounds or inorganic materials
C40B60/14 - for creating libraries
C40B70/00 - Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

G01R33/16 - Measuring susceptibility {

H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01F - MAGNETS

H01F1/401 - {diluted}
H01F1/407 - {Diluted non-magnetic ions in a magnetic cation-sublattice, e.g. perovskites, La1-x
H01F10/007 - {ultrathin or granular films
H01F10/1933 - {Perovskites}
H01F41/18 - by cathode sputtering
H01F41/34 - in patterns, e.g. by lithography

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S436/809 - Multifield plates or multicontainer arrays
Y10S436/81 - Tube, bottle, or dipstick

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DOE Contract Number:  

AC03-76SF00098

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

combinatorial; synthesis; novel; materials; methods; apparatus; preparation; substrate; array; diverse; predefined; regions; thereon; prepared; delivering; components; simultaneously; reacting; form; example; covalent; network; solids; ionic; molecular; particularly; inorganic; intermetallic; metal; alloys; ceramic; organic; organometallic; non-biological; polymers; composite; composites; combinations; etc; screened; useful; properties; including; electrical; thermal; mechanical; morphological; optical; magnetic; chemical; provides; parallel; analysis; organic polymers; inorganic materials; metallic materials; materials thereon; metallic material; provides methods; composite materials; ceramic material; organic materials; ceramic materials; metal alloy; composite material; organic polymer; metal alloys; organic material; predefined regions; diverse materials; novel materials; properties including; useful properties; organometallic materials; non-biological organic; parallel synthesis; organic composites; combinatorial synthesis; simultaneously reacting; regions thereon; molecular solids; network solids; covalent network; ionic solids; composite mat; delivering components; intermetallic materials; inorganic material; inorganic composites; omposite materials; ceramic mater; /427/436/