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Title: Detection of biological molecules using boronate-based chemical amplification and optical sensors

Abstract

Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.

Inventors:
 [1];  [2];  [3];  [4];  [5];  [6];  [7]
  1. Valencia, CA
  2. Los Angeles, CA
  3. Oakland, CA
  4. (Modesto, CA)
  5. Pleasanton, CA
  6. Menlo Park, CA
  7. Livermore, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
872763
Patent Number(s):
6002954
Assignee:
Regents of University of California (Oakland, CA); Minimed Inc. (Sylmar, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
detection; biological; molecules; boronate-based; chemical; amplification; optical; sensors; methods; provided; determination; concentration; levels; polyhydroxylated; compounds; particularly; glucose; utilize; analyte; transducer; immobilized; polymeric; matrix; implantable; biocompatible; interrogation; produces; signal; capable; external; patient; quantitation; achieved; measurement; emitted; polymeric matrix; biological molecules; optical sensors; optical sensor; methods utilize; chemical amplification; particularly glucose; emitted signal; polyhydroxylated compounds; biological levels; /600/

Citation Formats

Van Antwerp, William Peter, Mastrototaro, John Joseph, Lane, Stephen M, Satcher, Jr., Joe H., Darrow, Christopher B, Peyser, Thomas A, and Harder, Jennifer. Detection of biological molecules using boronate-based chemical amplification and optical sensors. United States: N. p., 1999. Web.
Van Antwerp, William Peter, Mastrototaro, John Joseph, Lane, Stephen M, Satcher, Jr., Joe H., Darrow, Christopher B, Peyser, Thomas A, & Harder, Jennifer. Detection of biological molecules using boronate-based chemical amplification and optical sensors. United States.
Van Antwerp, William Peter, Mastrototaro, John Joseph, Lane, Stephen M, Satcher, Jr., Joe H., Darrow, Christopher B, Peyser, Thomas A, and Harder, Jennifer. Fri . "Detection of biological molecules using boronate-based chemical amplification and optical sensors". United States. https://www.osti.gov/servlets/purl/872763.
@article{osti_872763,
title = {Detection of biological molecules using boronate-based chemical amplification and optical sensors},
author = {Van Antwerp, William Peter and Mastrototaro, John Joseph and Lane, Stephen M and Satcher, Jr., Joe H. and Darrow, Christopher B and Peyser, Thomas A and Harder, Jennifer},
abstractNote = {Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

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Works referenced in this record:

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