Title: Detection of biological molecules using boronate-based chemical amplification and optical sensors

Abstract

Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.

Inventors:

Van Antwerp, William Peter ^[1]; Mastrototaro, John Joseph ^[2]; Lane, Stephen M ^[3]; Satcher, Jr., Joe H. ^[4]; Darrow, Christopher B ^[5]; Peyser, Thomas A ^[6]; Harder, Jennifer ^[7]

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+ Show Inventor Affiliations

1. Valencia, CA
2. Los Angeles, CA
3. Oakland, CA
4. (Modesto, CA)
5. Pleasanton, CA
6. Menlo Park, CA
7. Livermore, CA

Issue Date:

1999-01-01

Research Org.:

Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

OSTI Identifier:

872763

Patent Number(s):

6002954

Assignee:

Regents of University of California (Oakland, CA); Minimed Inc. (Sylmar, CA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A61B5/14532 - {for measuring glucose, e.g. by tissue impedance measurement}
A61B5/1455 - using optical sensors, e.g. spectral photometrical oximeters
A61B5/1459 - invasive, e.g. introduced into the body by a catheter {

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/66 - involving blood sugars, e.g. galactose

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DOE Contract Number:  

W-7405-ENG-48

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

detection; biological; molecules; boronate-based; chemical; amplification; optical; sensors; methods; provided; determination; concentration; levels; polyhydroxylated; compounds; particularly; glucose; utilize; analyte; transducer; immobilized; polymeric; matrix; implantable; biocompatible; interrogation; produces; signal; capable; external; patient; quantitation; achieved; measurement; emitted; polymeric matrix; biological molecules; optical sensors; optical sensor; methods utilize; chemical amplification; particularly glucose; emitted signal; polyhydroxylated compounds; biological levels; /600/