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Title: DNA sequence similarity recognition by hybridization to short oligomers

Abstract

Methods are disclosed for the comparison of nucleic acid sequences. Data is generated by hybridizing sets of oligomers with target nucleic acids. The data thus generated is manipulated simultaneously with respect to both (i) matching between oligomers and (ii) matching between oligomers and putative reference sequences available in databases. Using data compression methods to manipulate this mutual information, sequences for the target can be constructed.

Inventors:
 [1]
  1. Westmont, IL
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
OSTI Identifier:
872753
Patent Number(s):
6001562
Assignee:
University of Chicago (Argonne, IL)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
W-31109-ENG-38
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
dna; sequence; similarity; recognition; hybridization; oligomers; methods; disclosed; comparison; nucleic; acid; sequences; data; generated; hybridizing; sets; target; acids; manipulated; simultaneously; respect; matching; ii; putative; reference; available; databases; compression; manipulate; mutual; information; constructed; compression methods; data compression; reference sequence; dna sequence; acid sequence; nucleic acid; acid sequences; nucleic acids; target nucleic; reference sequences; target nuclei; /435/999/

Citation Formats

Milosavljevic, Aleksandar. DNA sequence similarity recognition by hybridization to short oligomers. United States: N. p., 1999. Web.
Milosavljevic, Aleksandar. DNA sequence similarity recognition by hybridization to short oligomers. United States.
Milosavljevic, Aleksandar. Fri . "DNA sequence similarity recognition by hybridization to short oligomers". United States. https://www.osti.gov/servlets/purl/872753.
@article{osti_872753,
title = {DNA sequence similarity recognition by hybridization to short oligomers},
author = {Milosavljevic, Aleksandar},
abstractNote = {Methods are disclosed for the comparison of nucleic acid sequences. Data is generated by hybridizing sets of oligomers with target nucleic acids. The data thus generated is manipulated simultaneously with respect to both (i) matching between oligomers and (ii) matching between oligomers and putative reference sequences available in databases. Using data compression methods to manipulate this mutual information, sequences for the target can be constructed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

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Works referenced in this record:

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journal, January 1992


Hybridization analyses of arrayed cDNA libraries
journal, October 1991


Biological Evaluation of d 2 , an Algorithm for High-Performance Sequence Comparison
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Discovering simple DNA sequences by the algorithmic significance method
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Systematic sequencing of the Escherichia coli genome: analysis of the 0 – 2.4 min region
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1-Tuple DNA Sequencing: Computer Analysis
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