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Title: Method for improved selectivity in photo-activation of molecular agents

Abstract

A method for the treatment of a particular volume of plant or animal tissue comprising the steps of treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue. There is also disclosed a method for the treatment of cancer in plant or animal tissue and a method for producing at least one photo-activated molecular agent in a particular volume of a material.

Inventors:
 [1];  [2];  [1]
  1. Knoxville, TN
  2. Oak Ridge, TN
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
OSTI Identifier:
872734
Patent Number(s):
5998597
Assignee:
Photogen, Inc. (Knoxville, TN)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; improved; selectivity; photo-activation; molecular; agents; treatment; particular; volume; plant; animal; tissue; comprising; steps; treating; photo-active; agent; retains; portion; light; sufficient; promote; simultaneous; two-photon; excitation; retained; active; disclosed; cancer; producing; photo-activated; material; two-photon excitation; photo-activated molecular; simultaneous two-photon; photo-active molecular; molecular agent; animal tissue; particular volume; improved selectivity; molecular agents; tissue retains; tissue comprising; agent retained; light sufficient; /999/128/530/600/607/

Citation Formats

Fisher, Walter G, Wachter, Eric A, and Dees, H Craig. Method for improved selectivity in photo-activation of molecular agents. United States: N. p., 1999. Web.
Fisher, Walter G, Wachter, Eric A, & Dees, H Craig. Method for improved selectivity in photo-activation of molecular agents. United States.
Fisher, Walter G, Wachter, Eric A, and Dees, H Craig. Fri . "Method for improved selectivity in photo-activation of molecular agents". United States. https://www.osti.gov/servlets/purl/872734.
@article{osti_872734,
title = {Method for improved selectivity in photo-activation of molecular agents},
author = {Fisher, Walter G and Wachter, Eric A and Dees, H Craig},
abstractNote = {A method for the treatment of a particular volume of plant or animal tissue comprising the steps of treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue. There is also disclosed a method for the treatment of cancer in plant or animal tissue and a method for producing at least one photo-activated molecular agent in a particular volume of a material.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

Patent:

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