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Title: Method for improved selectivity in photo-activation of molecular agents

Abstract

A method for the treatment of a particular volume of plant or animal tissue comprising the steps of treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue. There is also disclosed a method for the treatment of cancer in plant or animal tissue and a method for producing at least one photo-activated molecular agent in a particular volume of a material.

Inventors:
 [1];  [2];  [1]
  1. Knoxville, TN
  2. Oak Ridge, TN
Issue Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
OSTI Identifier:
872734
Patent Number(s):
5998597
Assignee:
Photogen, Inc. (Knoxville, TN)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; improved; selectivity; photo-activation; molecular; agents; treatment; particular; volume; plant; animal; tissue; comprising; steps; treating; photo-active; agent; retains; portion; light; sufficient; promote; simultaneous; two-photon; excitation; retained; active; disclosed; cancer; producing; photo-activated; material; two-photon excitation; photo-activated molecular; simultaneous two-photon; photo-active molecular; molecular agent; animal tissue; particular volume; improved selectivity; molecular agents; tissue retains; tissue comprising; agent retained; light sufficient; /999/128/530/600/607/

Citation Formats

Fisher, Walter G, Wachter, Eric A, and Dees, H Craig. Method for improved selectivity in photo-activation of molecular agents. United States: N. p., 1999. Web.
Fisher, Walter G, Wachter, Eric A, & Dees, H Craig. Method for improved selectivity in photo-activation of molecular agents. United States.
Fisher, Walter G, Wachter, Eric A, and Dees, H Craig. Fri . "Method for improved selectivity in photo-activation of molecular agents". United States. https://www.osti.gov/servlets/purl/872734.
@article{osti_872734,
title = {Method for improved selectivity in photo-activation of molecular agents},
author = {Fisher, Walter G and Wachter, Eric A and Dees, H Craig},
abstractNote = {A method for the treatment of a particular volume of plant or animal tissue comprising the steps of treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue. There is also disclosed a method for the treatment of cancer in plant or animal tissue and a method for producing at least one photo-activated molecular agent in a particular volume of a material.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}

Works referenced in this record:

Two-step laser activation of hematoporphyrin derivative
journal, April 1982


Double resonance multiphoton ionization studies of high Rydberg states in nitric oxide (NO)
journal, June 1983


Dispersion of the two-photon cross section in rhodamine dyes
journal, October 1972


A simple conceptual model for two‐photon absorption
journal, January 1986


Multiphoton Spectroscopy
journal, October 1967


Laser two-photon excited fluorescence detector for microbore liquid chromatography
journal, August 1986


Titanium: Sapphire Laser as an Excitation Source in Two-Photon Spectroscopy
journal, February 1997


Theory of two-photon induced fluorescence anisotropy decay in membranes
journal, May 1993


Über Elementarakte mit zwei Quantensprüngen
journal, January 1931


Photodynamic Therapy for the Treatment of Squamous Cell Carcinoma Using Benzoporphyrin Derivative
journal, June 1994


A study on the possible involvement of nonlinear mechanism of light absorption by HpD with Nd: YAG laser
journal, January 1986


Photodynamic Therapy Using Pheophorbide a and Nd:YAG Laser
journal, January 1991


Photocarcinogenicity of psoralens used in PUVA treatment: Present status in mouse and man
journal, June 1990


Excited State Symmetry Assignment Through Polarized Two‐Photon Absorption Studies of Fluids
journal, September 1971


The multiphoton ionization spectrum of benzene
journal, May 1976


A new electronic state of ammonia observed by multiphoton ionization
journal, June 1978


Threshold dependence of laser‐induced optical breakdown on pulse duration
journal, March 1995


A review of the optical properties of biological tissues
journal, January 1990


The effect of spatial and temporal laser beam characteristics on two-photon absorption
journal, August 1975


Two-Photon Excitation in Ca F 2 : Eu 2 +
journal, September 1961


Photochemistry and Photobiology of Psoralens
journal, June 1979


High-performance liquid chromatographic studies of coal liquids by laser-based detectors
journal, June 1981


1993 Syntex Award Lecture Photomedicine and photodynamic therapy
journal, April 1994


Two-Photon Excitation Spectra of Polycyclic Aromatic Hydrocarbons
journal, November 1980


Very high detectability in two-photon spectroscopy
journal, May 1990


60-fsec pulse generation from a self-mode-locked Ti:sapphire laser
journal, January 1991


Clinical Applications of Photodynamic Therapy
journal, January 1994


Tunable dye laser pulse converter for production of picosecond pulses
journal, October 1974


Clinical and preclinical photodynamic therapy
journal, January 1995


Femtosecond Dynamics of Excited-State Evolution in [Ru(bpy)3]2+
journal, January 1997


The multiphoton ionization spectrum of t r a n s ‐1,3‐butadiene
journal, June 1976


The physics of photodynamic therapy
journal, April 1986


Photodynamic Therapy with a Diode Laser for Implanted Fibrosarcoma in Mice Employing Mono-L-Aspartyl Chlorin E 6
journal, October 1996


Photophysical and Photobiological Properties of Diporphyrin Ethers
journal, April 1991


The Concept Of Laser Phototherapy
journal, December 1996


The reaction of the psoralens with deoxyribonucleic acid
journal, February 1984


Photodynamic therapy using pheophorbide-a and Q-switched Nd:YAG Laser on implanted human hepatocellular carcinoma
journal, October 1991


The three‐photon spectrum of the 1 B 2 u 1 A 1 g transition in benzene: Analysis of vibronic and rotational structure
journal, December 1984


In vivo EXCITATION OF PHOTOSENSITIZERS BY INFRARED LIGHT
journal, August 1995


Laser two-photon excited fluorescence detection for high pressure liquid chromatography
journal, September 1977


Photophysical properties of the photosensitizer pheophorbide a studied at high photon flux densities
journal, February 1993


Two-Photon Excitation of 4'-Hydroxymethyl-4,5',8-Trimethylpsoralen
journal, January 1997


Two-photon molecular spectroscopy
journal, May 1974


Two-Color Two-Photon Excitation of Fluorescence
journal, October 1996


A condensed phase study of the benzene B 2 u A 1 g three-photon transition
journal, September 1986


Photoradiation Therapy. II. Cure of Animal Tumors With Hematoporphyrin and Light23
journal, July 1975


Pulse generation in a cw dye laser by mode−locked synchronous pumping
journal, January 1975


Photodynamic therapy with endogenous protoporphyrin
journal, June 1990


Two-photon excited molecular fluorescence in optically dense media
journal, November 1977


Photodynamic Therapy of Experimental Choroidal Melanoma Using Lipoprotein-delivered Benzoporphyrin
journal, January 1994


Properties and Applications of Photodynamic Therapy
journal, October 1989


Experimental investigation of ultrashort pulse laser-induced breakdown thresholds in aqueous media
journal, April 1996