Ultra-high-mass mass spectrometry with charge discrimination using cryogenic detectors
Abstract
An ultra-high-mass time-of-flight mass spectrometer using a cryogenic particle detector as an ion detector with charge discriminating capabilities. Cryogenic detectors have the potential for significantly improving the performance and sensitivity of time-of-flight mass spectrometers, and compared to ion multipliers they exhibit superior sensitivity for high-mass, slow-moving macromolecular ions and can be used as "stop" detectors in time-of-flight applications. In addition, their energy resolving capability can be used to measure the charge state of the ions. Charge discrimination is very valuable in all time-of-flight mass spectrometers. Using a cryogenically-cooled Nb-Al.sub.2 O.sub.3 -Nb superconductor-insulator-superconductor (SIS) tunnel junction (STJ) detector operating at 1.3 K as an ion detector in a time-of-flight mass spectrometer for large biomolecules it was found that the STJ detector has charge discrimination capabilities. Since the cryogenic STJ detector responds to ion energy and does not rely on secondary electron production, as in the conventionally used microchannel plate (MCP) detectors, the cryogenic detector therefore detects large molecular ions with a velocity-independent efficiency approaching 100%.
- Inventors:
-
- Berkeley, CA
- Oakland, CA
- Danville, CA
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- OSTI Identifier:
- 872715
- Patent Number(s):
- 5994694
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- ultra-high-mass; mass; spectrometry; charge; discrimination; cryogenic; detectors; time-of-flight; spectrometer; particle; detector; discriminating; capabilities; potential; significantly; improving; performance; sensitivity; spectrometers; compared; multipliers; exhibit; superior; high-mass; slow-moving; macromolecular; stop; applications; addition; energy; resolving; capability; measure; valuable; cryogenically-cooled; nb-al; -nb; superconductor-insulator-superconductor; sis; tunnel; junction; stj; operating; biomolecules; found; responds; rely; secondary; electron; production; conventionally; microchannel; plate; mcp; detects; molecular; velocity-independent; efficiency; approaching; 100; channel plate; time-of-flight mass; tunnel junction; mass spectrometers; mass spectrometer; mass spectrometry; microchannel plate; particle detector; secondary electron; significantly improving; flight mass; cryogenic particle; detector responds; cryogenic detectors; /250/
Citation Formats
Frank, Matthias, Mears, Carl A, Labov, Simon E, and Benner, W Henry. Ultra-high-mass mass spectrometry with charge discrimination using cryogenic detectors. United States: N. p., 1999.
Web.
Frank, Matthias, Mears, Carl A, Labov, Simon E, & Benner, W Henry. Ultra-high-mass mass spectrometry with charge discrimination using cryogenic detectors. United States.
Frank, Matthias, Mears, Carl A, Labov, Simon E, and Benner, W Henry. Fri .
"Ultra-high-mass mass spectrometry with charge discrimination using cryogenic detectors". United States. https://www.osti.gov/servlets/purl/872715.
@article{osti_872715,
title = {Ultra-high-mass mass spectrometry with charge discrimination using cryogenic detectors},
author = {Frank, Matthias and Mears, Carl A and Labov, Simon E and Benner, W Henry},
abstractNote = {An ultra-high-mass time-of-flight mass spectrometer using a cryogenic particle detector as an ion detector with charge discriminating capabilities. Cryogenic detectors have the potential for significantly improving the performance and sensitivity of time-of-flight mass spectrometers, and compared to ion multipliers they exhibit superior sensitivity for high-mass, slow-moving macromolecular ions and can be used as "stop" detectors in time-of-flight applications. In addition, their energy resolving capability can be used to measure the charge state of the ions. Charge discrimination is very valuable in all time-of-flight mass spectrometers. Using a cryogenically-cooled Nb-Al.sub.2 O.sub.3 -Nb superconductor-insulator-superconductor (SIS) tunnel junction (STJ) detector operating at 1.3 K as an ion detector in a time-of-flight mass spectrometer for large biomolecules it was found that the STJ detector has charge discrimination capabilities. Since the cryogenic STJ detector responds to ion energy and does not rely on secondary electron production, as in the conventionally used microchannel plate (MCP) detectors, the cryogenic detector therefore detects large molecular ions with a velocity-independent efficiency approaching 100%.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}
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Simultaneous measurement of flight time and energy of large matrix-assisted laser desorption ionization ions with a superconducting tunnel junction detector
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Biopolymer mass spectrometer with cryogenic particle detectors
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