Oncoprotein protein kinase
Abstract
An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD or 55 kD as determined by reducing SDS-PAGE, having serine and theonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.
- Inventors:
-
- San Diego, CA
- La Jolla, CA
- Issue Date:
- Research Org.:
- Univ. of California (United States)
- OSTI Identifier:
- 872710
- Patent Number(s):
- 5994513
- Application Number:
- 09/150,200
- Assignee:
- University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- FG03-86ER60429
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- oncoprotein; protein; kinase; isolated; polypeptide; jnk; characterized; molecular; weight; 46; kd; 55; determined; reducing; sds-page; serine; theonine; activity; phosphorylating; c-jun; n-terminal; activation; domain; polynucleotide; sequences; method; detection; provided; phosphorylates; affects; expression; ap-1; sites; phosphorylates c-jun; oncoprotein protein; ap-1 sites; protein kinase; reducing sds-page; kinase activity; jnk phosphorylates; activation domain; nucleotide sequences; nucleotide sequence; n-terminal activation; c-jun n-terminal; molecular weight; isolated polypeptide; polynucleotide sequences; theonine kinase; protein protein; /530/
Citation Formats
Karin, Michael, and Lin, Anning. Oncoprotein protein kinase. United States: N. p., 1999.
Web.
Karin, Michael, & Lin, Anning. Oncoprotein protein kinase. United States.
Karin, Michael, and Lin, Anning. Tue .
"Oncoprotein protein kinase". United States. https://www.osti.gov/servlets/purl/872710.
@article{osti_872710,
title = {Oncoprotein protein kinase},
author = {Karin, Michael and Lin, Anning},
abstractNote = {An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD or 55 kD as determined by reducing SDS-PAGE, having serine and theonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 30 00:00:00 EST 1999},
month = {Tue Nov 30 00:00:00 EST 1999}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.
journal, October 1994
- Minden, A.; Lin, A.; Smeal, T.
- Molecular and Cellular Biology, Vol. 14, Issue 10
pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.
journal, October 1990
- Kyriakis, J. M.; Avruch, J.
- Journal of Biological Chemistry, Vol. 265, Issue 28
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
journal, July 1990
- Boulton, T.; Yancopoulos, G.; Gregory, J.
- Science, Vol. 249, Issue 4964
Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
journal, February 1990
- Anderson, Neil G.; Maller, James L.; Tonks, Nicholas K.
- Nature, Vol. 343, Issue 6259
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
journal, November 1993
- Hibi, M.; Lin, A.; Smeal, T.
- Genes & Development, Vol. 7, Issue 11
Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.
journal, June 1992
- Adler, V.; Franklin, C. C.; Kraft, A. S.
- Proceedings of the National Academy of Sciences, Vol. 89, Issue 12
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
journal, May 1991
- Boulton, Teri G.; Nye, Steven H.; Robbins, David J.
- Cell, Vol. 65, Issue 4
Parallel signal processing among mammalian MAPKs
journal, March 1995
- Cano, Eva; Mahadevan, Louis C.
- Trends in Biochemical Sciences, Vol. 20, Issue 3
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
journal, March 1994
- Dérijard, Benoit; Hibi, Masahiko; Wu, I-Huan
- Cell, Vol. 76, Issue 6
Phosphorylation of c-jun mediated by MAP kinases
journal, October 1991
- Pulverer, Bernd J.; Kyriakis, John M.; Avruch, Joseph
- Nature, Vol. 353, Issue 6345