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Title: Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media

Abstract

Optical Doppler tomography permits imaging of fluid flow velocity in highly scattering media. The tomography system combines Doppler velocimetry with high spatial resolution of partially coherent optical interferometry to measure fluid flow velocity at discrete spatial locations. Noninvasive in vivo imaging of blood flow dynamics and tissue structures with high spatial resolutions of the order of 2 to 10 microns is achieved in biological systems. The backscattered interference signals derived from the interferometer may be analyzed either through power spectrum determination to obtain the position and velocity of each particle in the fluid flow sample at each pixel, or the interference spectral density may be analyzed at each frequency in the spectrum to obtain the positions and velocities of the particles in a cross-section to which the interference spectral density corresponds. The realized resolutions of optical Doppler tomography allows noninvasive in vivo imaging of both blood microcirculation and tissue structure surrounding the vessel which has significance for biomedical research and clinical applications.

Inventors:
 [1];  [2];  [2]
  1. Laguna Niguel, CA
  2. Irvine, CA
Issue Date:
Research Org.:
Univ. of California (United States)
OSTI Identifier:
872695
Patent Number(s):
5991697
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
G - PHYSICS G01 - MEASURING G01P - MEASURING LINEAR OR ANGULAR SPEED, ACCELERATION, DECELERATION, OR SHOCK
DOE Contract Number:  
FG03-91ER61227
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; apparatus; optical; doppler; tomographic; imaging; fluid; flow; velocity; highly; scattering; media; tomography; permits; combines; velocimetry; spatial; resolution; partially; coherent; interferometry; measure; discrete; locations; noninvasive; vivo; blood; dynamics; tissue; structures; resolutions; 10; microns; achieved; biological; systems; backscattered; interference; signals; derived; interferometer; analyzed; power; spectrum; determination; obtain; position; particle; sample; pixel; spectral; density; frequency; positions; velocities; particles; cross-section; corresponds; realized; allows; microcirculation; structure; surrounding; vessel; significance; biomedical; clinical; applications; spectral density; blood flow; highly scattering; biological systems; fluid flow; spatial resolution; flow velocity; scattering media; optical doppler; structure surrounding; partially coherent; tomographic imaging; coherent optical; measure fluid; doppler velocimetry; interference signal; /702/356/382/600/

Citation Formats

Nelson, John Stuart, Milner, Thomas Edward, and Chen, Zhongping. Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media. United States: N. p., 1999. Web.
Nelson, John Stuart, Milner, Thomas Edward, & Chen, Zhongping. Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media. United States.
Nelson, John Stuart, Milner, Thomas Edward, and Chen, Zhongping. Fri . "Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media". United States. https://www.osti.gov/servlets/purl/872695.
@article{osti_872695,
title = {Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media},
author = {Nelson, John Stuart and Milner, Thomas Edward and Chen, Zhongping},
abstractNote = {Optical Doppler tomography permits imaging of fluid flow velocity in highly scattering media. The tomography system combines Doppler velocimetry with high spatial resolution of partially coherent optical interferometry to measure fluid flow velocity at discrete spatial locations. Noninvasive in vivo imaging of blood flow dynamics and tissue structures with high spatial resolutions of the order of 2 to 10 microns is achieved in biological systems. The backscattered interference signals derived from the interferometer may be analyzed either through power spectrum determination to obtain the position and velocity of each particle in the fluid flow sample at each pixel, or the interference spectral density may be analyzed at each frequency in the spectrum to obtain the positions and velocities of the particles in a cross-section to which the interference spectral density corresponds. The realized resolutions of optical Doppler tomography allows noninvasive in vivo imaging of both blood microcirculation and tissue structure surrounding the vessel which has significance for biomedical research and clinical applications.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

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Works referenced in this record:

Characterization of fluid flow velocity by optical Doppler tomography
journal, January 1995


Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography
journal, January 1997


Optical coherence tomography with the "spectral radar": fast optical analysis in volume scatterers by short-coherence interferometry
conference, December 1996


Distributed laser Doppler velocimeter
journal, January 1991


Optical Doppler Tomography: Imaging in vivo Blood Flow Dynamics Following Pharmacological Intervention and Photodynamic Therapy
journal, January 1998


Optical low-coherence reflectometry to enhance monte Carlo modeling of skin
journal, January 1997


Optical coherence tomography
journal, November 1991


Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media
journal, January 1997