Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
Abstract
A luminescent semiconductor nanocrystal compound is described which is capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation (luminescing) in a narrow wavelength band and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation--when excited by an electromagnetic radiation source (of narrow or broad bandwidth) or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The luminescent semiconductor nanocrystal compound is linked to an affinity molecule to form an organo luminescent semiconductor nanocrystal probe capable of bonding with a detectable substance in a material being analyzed, and capable of emitting electromagnetic radiation in a narrow wavelength band and/or absorbing, scattering, or diffracting energy when excited by an electromagnetic radiation source (of narrow or broad bandwidth) or a particle beam. The probe is stable to repeated exposure to light in the presence of oxygen and/or other radicals. Further described is a process for making the luminescent semiconductor nanocrystal compound and for making the organo luminescent semiconductor nanocrystal probe comprising the luminescent semiconductor nanocrystal compound linked to an affinity molecule capable ofmore »
- Inventors:
-
- Pinole, CA
- (Albany, CA)
- Oakland, CA
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- OSTI Identifier:
- 872692
- Patent Number(s):
- 5990479
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- DOE Contract Number:
- AC03-76SF00098
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- organo; luminescent; semiconductor; nanocrystal; probes; biological; applications; process; compound; described; capable; linking; affinity; molecule; comprises; emitting; electromagnetic; radiation; luminescing; narrow; wavelength; band; absorbing; energy; scattering; diffracting; radiation-when; excited; source; broad; bandwidth; particle; beam; agent; portion; linked; form; probe; bonding; detectable; substance; material; analyzed; stable; repeated; exposure; light; presence; oxygen; radicals; comprising; determine; luminescent semiconductor; particle beam; electromagnetic radiation; radiation source; broad band; broad bandwidth; wavelength band; semiconductor nanocrystal; narrow wavelength; portion capable; probe capable; linking agent; /250/252/356/378/422/436/
Citation Formats
Weiss, Shimon, Bruchez, Jr., Marcel, and Alivisatos, Paul. Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes. United States: N. p., 1999.
Web.
Weiss, Shimon, Bruchez, Jr., Marcel, & Alivisatos, Paul. Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes. United States.
Weiss, Shimon, Bruchez, Jr., Marcel, and Alivisatos, Paul. Fri .
"Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes". United States. https://www.osti.gov/servlets/purl/872692.
@article{osti_872692,
title = {Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes},
author = {Weiss, Shimon and Bruchez, Jr., Marcel and Alivisatos, Paul},
abstractNote = {A luminescent semiconductor nanocrystal compound is described which is capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation (luminescing) in a narrow wavelength band and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation--when excited by an electromagnetic radiation source (of narrow or broad bandwidth) or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The luminescent semiconductor nanocrystal compound is linked to an affinity molecule to form an organo luminescent semiconductor nanocrystal probe capable of bonding with a detectable substance in a material being analyzed, and capable of emitting electromagnetic radiation in a narrow wavelength band and/or absorbing, scattering, or diffracting energy when excited by an electromagnetic radiation source (of narrow or broad bandwidth) or a particle beam. The probe is stable to repeated exposure to light in the presence of oxygen and/or other radicals. Further described is a process for making the luminescent semiconductor nanocrystal compound and for making the organo luminescent semiconductor nanocrystal probe comprising the luminescent semiconductor nanocrystal compound linked to an affinity molecule capable of bonding to a detectable substance. A process is also described for using the probe to determine the presence of a detectable substance in a material.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}
Works referenced in this record:
(CdSe)ZnS Core−Shell Quantum Dots: Synthesis and Characterization of a Size Series of Highly Luminescent Nanocrystallites
journal, November 1997
- Dabbousi, B. O.; Rodriguez-Viejo, J.; Mikulec, F. V.
- The Journal of Physical Chemistry B, Vol. 101, Issue 46, p. 9463-9475
Epitaxial Growth of Highly Luminescent CdSe/CdS Core/Shell Nanocrystals with Photostability and Electronic Accessibility
journal, July 1997
- Peng, Xiaogang; Schlamp, Michael C.; Kadavanich, Andreas V.
- Journal of the American Chemical Society, Vol. 119, Issue 30, p. 7019-7029