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Title: Micro injector sample delivery system for charged molecules

Abstract

A micro injector sample delivery system for charged molecules. The injector is used for collecting and delivering controlled amounts of charged molecule samples for subsequent analysis. The injector delivery system can be scaled to large numbers (>96) for sample delivery to massively parallel high throughput analysis systems. The essence of the injector system is an electric field controllable loading tip including a section of porous material. By applying the appropriate polarity bias potential to the injector tip, charged molecules will migrate into porous material, and by reversing the polarity bias potential the molecules are ejected or forced away from the tip. The invention has application for uptake of charged biological molecules (e.g. proteins, nucleic acids, polymers, etc.) for delivery to analytical systems, and can be used in automated sample delivery systems.

Inventors:
 [1];  [1]
  1. Livermore, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
872645
Patent Number(s):
5980713
Application Number:
08/705447
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
micro; injector; sample; delivery; charged; molecules; collecting; delivering; controlled; amounts; molecule; samples; subsequent; analysis; scaled; 96; massively; parallel; throughput; systems; essence; electric; field; controllable; loading; tip; including; section; porous; material; applying; appropriate; polarity; bias; potential; migrate; reversing; ejected; forced; application; uptake; biological; proteins; nucleic; acids; polymers; etc; analytical; automated; bias potential; massively parallel; biological molecules; controlled amounts; subsequent analysis; porous material; electric field; nucleic acid; nucleic acids; controlled amount; charged molecules; sample delivery; field control; charged biological; micro injector; delivery systems; charged molecule; injector sample; /204/

Citation Formats

Davidson, James C, and Balch, Joseph W. Micro injector sample delivery system for charged molecules. United States: N. p., 1999. Web.
Davidson, James C, & Balch, Joseph W. Micro injector sample delivery system for charged molecules. United States.
Davidson, James C, and Balch, Joseph W. Tue . "Micro injector sample delivery system for charged molecules". United States. https://www.osti.gov/servlets/purl/872645.
@article{osti_872645,
title = {Micro injector sample delivery system for charged molecules},
author = {Davidson, James C and Balch, Joseph W},
abstractNote = {A micro injector sample delivery system for charged molecules. The injector is used for collecting and delivering controlled amounts of charged molecule samples for subsequent analysis. The injector delivery system can be scaled to large numbers (>96) for sample delivery to massively parallel high throughput analysis systems. The essence of the injector system is an electric field controllable loading tip including a section of porous material. By applying the appropriate polarity bias potential to the injector tip, charged molecules will migrate into porous material, and by reversing the polarity bias potential the molecules are ejected or forced away from the tip. The invention has application for uptake of charged biological molecules (e.g. proteins, nucleic acids, polymers, etc.) for delivery to analytical systems, and can be used in automated sample delivery systems.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {11}
}

Patent:

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