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Title: Direct detection of x-rays for protein crystallography employing a thick, large area CCD

Abstract

An apparatus and method for directly determining the crystalline structure of a protein crystal. The crystal is irradiated by a finely collimated x-ray beam. The interaction of the x-ray beam with the crystal produces scattered x-rays. These scattered x-rays are detected by means of a large area, thick CCD which is capable of measuring a significant number of scattered x-rays which impact its surface. The CCD is capable of detecting the position of impact of the scattered x-ray on the surface of the CCD and the quantity of scattered x-rays which impact the same cell or pixel. This data is then processed in real-time and the processed data is outputted to produce a image of the structure of the crystal. If this crystal is a protein the molecular structure of the protein can be determined from the data received.

Inventors:
 [1];  [2]
  1. Wheaton, IL
  2. Ann Arbor, MI
Issue Date:
Research Org.:
Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)
OSTI Identifier:
872638
Patent Number(s):
5978444
Assignee:
United States of America as represented by United States (Washington, DC)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC02-76CH03000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
direct; detection; x-rays; protein; crystallography; employing; thick; ccd; apparatus; method; directly; determining; crystalline; structure; crystal; irradiated; finely; collimated; x-ray; beam; interaction; produces; scattered; detected; means; capable; measuring; significant; impact; surface; detecting; position; quantity; cell; pixel; data; processed; real-time; outputted; produce; image; molecular; determined; received; direct detection; x-ray beam; crystalline structure; molecular structure; collimated x-ray; scattered x-ray; protein crystal; directly determining; line structure; /378/

Citation Formats

Atac, Muzaffer, and McKay, Timothy. Direct detection of x-rays for protein crystallography employing a thick, large area CCD. United States: N. p., 1999. Web.
Atac, Muzaffer, & McKay, Timothy. Direct detection of x-rays for protein crystallography employing a thick, large area CCD. United States.
Atac, Muzaffer, and McKay, Timothy. Fri . "Direct detection of x-rays for protein crystallography employing a thick, large area CCD". United States. https://www.osti.gov/servlets/purl/872638.
@article{osti_872638,
title = {Direct detection of x-rays for protein crystallography employing a thick, large area CCD},
author = {Atac, Muzaffer and McKay, Timothy},
abstractNote = {An apparatus and method for directly determining the crystalline structure of a protein crystal. The crystal is irradiated by a finely collimated x-ray beam. The interaction of the x-ray beam with the crystal produces scattered x-rays. These scattered x-rays are detected by means of a large area, thick CCD which is capable of measuring a significant number of scattered x-rays which impact its surface. The CCD is capable of detecting the position of impact of the scattered x-ray on the surface of the CCD and the quantity of scattered x-rays which impact the same cell or pixel. This data is then processed in real-time and the processed data is outputted to produce a image of the structure of the crystal. If this crystal is a protein the molecular structure of the protein can be determined from the data received.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

Patent:

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