Direct detection of x-rays for protein crystallography employing a thick, large area CCD
Abstract
An apparatus and method for directly determining the crystalline structure of a protein crystal. The crystal is irradiated by a finely collimated x-ray beam. The interaction of the x-ray beam with the crystal produces scattered x-rays. These scattered x-rays are detected by means of a large area, thick CCD which is capable of measuring a significant number of scattered x-rays which impact its surface. The CCD is capable of detecting the position of impact of the scattered x-ray on the surface of the CCD and the quantity of scattered x-rays which impact the same cell or pixel. This data is then processed in real-time and the processed data is outputted to produce a image of the structure of the crystal. If this crystal is a protein the molecular structure of the protein can be determined from the data received.
- Inventors:
-
- Wheaton, IL
- Ann Arbor, MI
- Issue Date:
- Research Org.:
- Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States)
- OSTI Identifier:
- 872638
- Patent Number(s):
- 5978444
- Assignee:
- United States of America as represented by United States (Washington, DC)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC02-76CH03000
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- direct; detection; x-rays; protein; crystallography; employing; thick; ccd; apparatus; method; directly; determining; crystalline; structure; crystal; irradiated; finely; collimated; x-ray; beam; interaction; produces; scattered; detected; means; capable; measuring; significant; impact; surface; detecting; position; quantity; cell; pixel; data; processed; real-time; outputted; produce; image; molecular; determined; received; direct detection; x-ray beam; crystalline structure; molecular structure; collimated x-ray; scattered x-ray; protein crystal; directly determining; line structure; /378/
Citation Formats
Atac, Muzaffer, and McKay, Timothy. Direct detection of x-rays for protein crystallography employing a thick, large area CCD. United States: N. p., 1999.
Web.
Atac, Muzaffer, & McKay, Timothy. Direct detection of x-rays for protein crystallography employing a thick, large area CCD. United States.
Atac, Muzaffer, and McKay, Timothy. Fri .
"Direct detection of x-rays for protein crystallography employing a thick, large area CCD". United States. https://www.osti.gov/servlets/purl/872638.
@article{osti_872638,
title = {Direct detection of x-rays for protein crystallography employing a thick, large area CCD},
author = {Atac, Muzaffer and McKay, Timothy},
abstractNote = {An apparatus and method for directly determining the crystalline structure of a protein crystal. The crystal is irradiated by a finely collimated x-ray beam. The interaction of the x-ray beam with the crystal produces scattered x-rays. These scattered x-rays are detected by means of a large area, thick CCD which is capable of measuring a significant number of scattered x-rays which impact its surface. The CCD is capable of detecting the position of impact of the scattered x-ray on the surface of the CCD and the quantity of scattered x-rays which impact the same cell or pixel. This data is then processed in real-time and the processed data is outputted to produce a image of the structure of the crystal. If this crystal is a protein the molecular structure of the protein can be determined from the data received.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}