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Title: Neutron capture therapies

Abstract

In one embodiment there is provided an application of the .sup.10 B(n,.alpha.).sup.7 Li nuclear reaction or other neutron capture reactions for the treatment of rheumatoid arthritis. This application, called Boron Neutron Capture Synovectomy (BNCS), requires substantially altered demands on neutron beam design than for instance treatment of deep seated tumors. Considerations for neutron beam design for the treatment of arthritic joints via BNCS are provided for, and comparisons with the design requirements for Boron Neutron Capture Therapy (BNCT) of tumors are made. In addition, exemplary moderator/reflector assemblies are provided which produce intense, high-quality neutron beams based on (p,n) accelerator-based reactions. In another embodiment there is provided the use of deuteron-based charged particle reactions to be used as sources for epithermal or thermal neutron beams for neutron capture therapies. Many d,n reactions (e.g. using deuterium, tritium or beryllium targets) are very prolific at relatively low deuteron energies.

Inventors:
 [1];  [2];  [3]
  1. Cambridge, MA
  2. Newton, MA
  3. Winchester, MA
Issue Date:
Research Org.:
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Newton Scientific, Inc. (Cambridge, MA)
OSTI Identifier:
872624
Patent Number(s):
5976066
Assignee:
Massachusetts Institute of Technology (Cambridge, MA); Newton Scientific, Inc. (Cambridge, MA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
DOE Contract Number:  
FG02-89ER60874
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
neutron; capture; therapies; embodiment; provided; application; 10; alpha; nuclear; reaction; reactions; treatment; rheumatoid; arthritis; called; boron; synovectomy; bncs; requires; substantially; altered; demands; beam; design; instance; deep; seated; tumors; considerations; arthritic; joints; via; comparisons; requirements; therapy; bnct; addition; exemplary; moderator; reflector; assemblies; produce; intense; high-quality; beams; based; accelerator-based; deuteron-based; charged; particle; sources; epithermal; thermal; deuterium; tritium; beryllium; targets; prolific; relatively; deuteron; energies; thermal neutron; neutron capture; charged particle; boron neutron; capture therapy; nuclear reaction; neutron beam; neutron beams; rheumatoid arthritis; capture reactions; /600/

Citation Formats

Yanch, Jacquelyn C, Shefer, Ruth E, and Klinkowstein, Robert E. Neutron capture therapies. United States: N. p., 1999. Web.
Yanch, Jacquelyn C, Shefer, Ruth E, & Klinkowstein, Robert E. Neutron capture therapies. United States.
Yanch, Jacquelyn C, Shefer, Ruth E, and Klinkowstein, Robert E. Fri . "Neutron capture therapies". United States. https://www.osti.gov/servlets/purl/872624.
@article{osti_872624,
title = {Neutron capture therapies},
author = {Yanch, Jacquelyn C and Shefer, Ruth E and Klinkowstein, Robert E},
abstractNote = {In one embodiment there is provided an application of the .sup.10 B(n,.alpha.).sup.7 Li nuclear reaction or other neutron capture reactions for the treatment of rheumatoid arthritis. This application, called Boron Neutron Capture Synovectomy (BNCS), requires substantially altered demands on neutron beam design than for instance treatment of deep seated tumors. Considerations for neutron beam design for the treatment of arthritic joints via BNCS are provided for, and comparisons with the design requirements for Boron Neutron Capture Therapy (BNCT) of tumors are made. In addition, exemplary moderator/reflector assemblies are provided which produce intense, high-quality neutron beams based on (p,n) accelerator-based reactions. In another embodiment there is provided the use of deuteron-based charged particle reactions to be used as sources for epithermal or thermal neutron beams for neutron capture therapies. Many d,n reactions (e.g. using deuterium, tritium or beryllium targets) are very prolific at relatively low deuteron energies.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

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Works referenced in this record:

Accelerator-based epithermal neutron beam design for neutron capture therapy
journal, May 1992