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Title: Computer-aided visualization and analysis system for sequence evaluation

Abstract

A computer system (1) for analyzing nucleic acid sequences is provided. The computer system is used to perform multiple methods for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acid probes. The results of individual experiments may be improved by processing nucleic acid sequences together. Comparative analysis of multiple experiments is also provided by displaying reference sequences in one area (814) and sample sequences in another area (816) on a display device (3).

Inventors:
 [1]
  1. Palo Alto, CA
Issue Date:
Research Org.:
Affymetrix, Inc. (Santa Clara, CA)
OSTI Identifier:
872618
Patent Number(s):
5974164
Application Number:
5974164
Assignee:
Affymetrix, Inc. (Santa Clara, CA)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
DOE Contract Number:  
FG03-92ER81275
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
computer-aided; visualization; analysis; sequence; evaluation; computer; analyzing; nucleic; acid; sequences; provided; perform; multiple; methods; determining; bases; fluorescence; intensities; hybridized; probes; results; individual; experiments; improved; processing; comparative; displaying; reference; 814; sample; 816; display; device; comparative analysis; reference sequence; acid probes; acid sequence; nucleic acid; acid sequences; acid probe; display device; sequence evaluation; sample sequences; analyzing nucleic; processing nucleic; multiple experiments; multiple methods; computer-aided visualization; reference sequences; perform multiple; fluorescence intensities; form multiple; displaying reference; individual experiments; hybridized nucleic; /382/435/999/

Citation Formats

Chee, Mark S. Computer-aided visualization and analysis system for sequence evaluation. United States: N. p., 1999. Web.
Chee, Mark S. Computer-aided visualization and analysis system for sequence evaluation. United States.
Chee, Mark S. Tue . "Computer-aided visualization and analysis system for sequence evaluation". United States. https://www.osti.gov/servlets/purl/872618.
@article{osti_872618,
title = {Computer-aided visualization and analysis system for sequence evaluation},
author = {Chee, Mark S},
abstractNote = {A computer system (1) for analyzing nucleic acid sequences is provided. The computer system is used to perform multiple methods for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acid probes. The results of individual experiments may be improved by processing nucleic acid sequences together. Comparative analysis of multiple experiments is also provided by displaying reference sequences in one area (814) and sample sequences in another area (816) on a display device (3).},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {10}
}

Works referenced in this record:

An Algorithm for the DNA Sequence Generation from k-Tuple Word Contents of the Minimal Number of Random Fragments
journal, April 1991


DNA sequencing by hybridization: 100 bases read by a non-gel-based method.
journal, November 1991


DNA sequence determination by hybridization: a strategy for efficient large-scale sequencing
journal, June 1993


A sequence assembly and editing program for efficient management of large projects
journal, January 1991