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Title: Senescence responsive transcriptional element

Abstract

Recombinant polynucleotides have expression control sequences that have a senescence responsive element and a minimal promoter, and which are operatively linked to a heterologous nucleotide sequence. The molecules are useful for achieving high levels of expression of genes in senescent cells. Methods of inhibiting expression of genes in senescent cells also are provided.

Inventors:
 [1];  [1]
  1. Berkeley, CA
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
872580
Patent Number(s):
5965543
Assignee:
Geron Corporation (Menlo Park, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
senescence; responsive; transcriptional; element; recombinant; polynucleotides; expression; control; sequences; minimal; promoter; operatively; linked; heterologous; nucleotide; sequence; molecules; useful; achieving; levels; genes; senescent; cells; methods; inhibiting; provided; nucleotide sequence; operatively linked; senescence responsive; control sequences; responsive element; control sequence; /514/999/

Citation Formats

Campisi, Judith, and Testori, Alessandro. Senescence responsive transcriptional element. United States: N. p., 1999. Web.
Campisi, Judith, & Testori, Alessandro. Senescence responsive transcriptional element. United States.
Campisi, Judith, and Testori, Alessandro. Fri . "Senescence responsive transcriptional element". United States. https://www.osti.gov/servlets/purl/872580.
@article{osti_872580,
title = {Senescence responsive transcriptional element},
author = {Campisi, Judith and Testori, Alessandro},
abstractNote = {Recombinant polynucleotides have expression control sequences that have a senescence responsive element and a minimal promoter, and which are operatively linked to a heterologous nucleotide sequence. The molecules are useful for achieving high levels of expression of genes in senescent cells. Methods of inhibiting expression of genes in senescent cells also are provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

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Works referenced in this record:

Regulation of collagenase and collagenase mRNA production in early- and late-passage human diploid fibroblasts
journal, February 1989


Aging and Cancer: The Double-Edged Sword of Replicative Senescence
journal, April 1997


Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema
journal, December 1992


Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity
journal, September 1989


Replicative Senescence: An Old Lives' Tale?
journal, February 1996


Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis.
journal, October 1995