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Title: Inhibition of selectin binding

Abstract

This invention provides a system for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 10.sup.6 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, this system can be used to palliate certain inflammatory and immunological conditions.

Inventors:
 [1];  [2];  [3];  [2]
  1. Rodeo, CA
  2. Albany, CA
  3. New Delhi, IN
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
872565
Patent Number(s):
5962422
Application Number:
08/807428
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
inhibition; selectin; binding; provides; inhibiting; cells; expressing; p-; l-selectin; surface; corresponding; ligand; covalently; crosslinked; lipid; composition; prepared; saccharides; acidic; separate; lipids; interposed; inhibit; achieved; effective; oligosaccharide; concentration; 10; fold; below; free; saccharide; selectins; involved; recruiting; sites; injury; palliate; inflammatory; immunological; conditions; recruiting cells; selectin binding; separate lipids; oligosaccharide concentration; expressing p-; fold below; free saccharide; lipid composition; effective oligosaccharide; covalently crosslinked; crosslinked lipid; corresponding ligand; immunological conditions; inhibit binding; /514/435/

Citation Formats

Nagy, Jon O, Spevak, Wayne R, Dasgupta, Falguni, and Bertozzi, Carolyn. Inhibition of selectin binding. United States: N. p., 1999. Web.
Nagy, Jon O, Spevak, Wayne R, Dasgupta, Falguni, & Bertozzi, Carolyn. Inhibition of selectin binding. United States.
Nagy, Jon O, Spevak, Wayne R, Dasgupta, Falguni, and Bertozzi, Carolyn. Fri . "Inhibition of selectin binding". United States. https://www.osti.gov/servlets/purl/872565.
@article{osti_872565,
title = {Inhibition of selectin binding},
author = {Nagy, Jon O and Spevak, Wayne R and Dasgupta, Falguni and Bertozzi, Carolyn},
abstractNote = {This invention provides a system for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 10.sup.6 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, this system can be used to palliate certain inflammatory and immunological conditions.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

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