Inhibition of selectin binding
Abstract
This invention provides a system for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 10.sup.6 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, this system can be used to palliate certain inflammatory and immunological conditions.
- Inventors:
-
- Rodeo, CA
- Albany, CA
- New Delhi, IN
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- OSTI Identifier:
- 872565
- Patent Number(s):
- 5962422
- Application Number:
- 08/807428
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC03-76SF00098
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- inhibition; selectin; binding; provides; inhibiting; cells; expressing; p-; l-selectin; surface; corresponding; ligand; covalently; crosslinked; lipid; composition; prepared; saccharides; acidic; separate; lipids; interposed; inhibit; achieved; effective; oligosaccharide; concentration; 10; fold; below; free; saccharide; selectins; involved; recruiting; sites; injury; palliate; inflammatory; immunological; conditions; recruiting cells; selectin binding; separate lipids; oligosaccharide concentration; expressing p-; fold below; free saccharide; lipid composition; effective oligosaccharide; covalently crosslinked; crosslinked lipid; corresponding ligand; immunological conditions; inhibit binding; /514/435/
Citation Formats
Nagy, Jon O, Spevak, Wayne R, Dasgupta, Falguni, and Bertozzi, Carolyn. Inhibition of selectin binding. United States: N. p., 1999.
Web.
Nagy, Jon O, Spevak, Wayne R, Dasgupta, Falguni, & Bertozzi, Carolyn. Inhibition of selectin binding. United States.
Nagy, Jon O, Spevak, Wayne R, Dasgupta, Falguni, and Bertozzi, Carolyn. Fri .
"Inhibition of selectin binding". United States. https://www.osti.gov/servlets/purl/872565.
@article{osti_872565,
title = {Inhibition of selectin binding},
author = {Nagy, Jon O and Spevak, Wayne R and Dasgupta, Falguni and Bertozzi, Carolyn},
abstractNote = {This invention provides a system for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 10.sup.6 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, this system can be used to palliate certain inflammatory and immunological conditions.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}
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