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Title: Conjugate and method for forming aminomethyl phosphorus conjugates

Abstract

A method of forming phosphine-amine conjugates includes reacting a hydroxymethyl phosphine group of an amine-free first molecule with at least one free amine group of a second molecule to covalently bond the first molecule with the second molecule through an aminomethyl phosphorus linkage and the conjugates formed thereby.

Inventors:
 [1];  [1];  [1];  [1];  [1]
  1. Columbia, MO
Issue Date:
Research Org.:
Univ. of Missouri, Columbia, MO (United States)
OSTI Identifier:
872500
Patent Number(s):
5948386
Assignee:
Curators of University of Missouri (Columbia, MO)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
FG02-89ER60875
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
conjugate; method; forming; aminomethyl; phosphorus; conjugates; phosphine-amine; reacting; hydroxymethyl; phosphine; amine-free; molecule; free; amine; covalently; bond; linkage; formed; hydroxymethyl phosphine; /424/999/

Citation Formats

Katti, Kattesh V, Berning, Douglas E, Volkert, Wynn A, Ketring, Alan R, and Churchill, Robert. Conjugate and method for forming aminomethyl phosphorus conjugates. United States: N. p., 1999. Web.
Katti, Kattesh V, Berning, Douglas E, Volkert, Wynn A, Ketring, Alan R, & Churchill, Robert. Conjugate and method for forming aminomethyl phosphorus conjugates. United States.
Katti, Kattesh V, Berning, Douglas E, Volkert, Wynn A, Ketring, Alan R, and Churchill, Robert. Fri . "Conjugate and method for forming aminomethyl phosphorus conjugates". United States. https://www.osti.gov/servlets/purl/872500.
@article{osti_872500,
title = {Conjugate and method for forming aminomethyl phosphorus conjugates},
author = {Katti, Kattesh V and Berning, Douglas E and Volkert, Wynn A and Ketring, Alan R and Churchill, Robert},
abstractNote = {A method of forming phosphine-amine conjugates includes reacting a hydroxymethyl phosphine group of an amine-free first molecule with at least one free amine group of a second molecule to covalently bond the first molecule with the second molecule through an aminomethyl phosphorus linkage and the conjugates formed thereby.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

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Works referenced in this record:

Aniline derivatives of tetrakis(hydromethyl)phosphonium chloride
journal, August 1972


Urease immobilized on chitosan membrane: Preparation and properties
journal, January 1990


Intermediate for Flame-Resistant Polymers - Reactions of Tetrakis(hydroxymethyl)phosphonium Chloride
journal, January 1956


Vehicles, Chelators, and Radionuclides:  Choosing the “Building Blocks” of an Effective Therapeutic Radioimmunoconjugate
journal, January 1996


Further advances in the chemistry of mannich bases
journal, January 1990


Protease immobilization onto porous chitosan beads
journal, January 1991


P(CH2OH)3? a new coupling reagent for the covalent immobilisation of enzymes
journal, January 1994


p-Maleimidophenyl isocyanate: a novel heterobifunctional linker for hydroxyl to thiol coupling
journal, May 1993