Electro-osmotically driven liquid delivery method and apparatus
Abstract
Method and apparatus for controlling precisely the composition and delivery of liquid at sub-.mu.L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-.mu.L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column.
- Inventors:
-
- Fremont, CA
- Livermore, CA
- Pleasanton, CA
- Stanford, CA
- Issue Date:
- Research Org.:
- Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
- OSTI Identifier:
- 872464
- Patent Number(s):
- 5942093
- Assignee:
- Sandia Corporation (Livermore, CA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- electro-osmotically; driven; liquid; delivery; method; apparatus; controlling; precisely; composition; sub-; flow; rate; embodiment; gradient; generates; dynamic; flows; rates; merging; plurality; electro-osmotic; delivered; arms; attached; mixing; connector; mix; receiving; means; preferably; column; inlet; placed; corresponding; solution; reservoir; independent; programmable; high-voltage; power; supplies; apply; voltage; reservoirs; regulate; arm; changed; time; according; deliver; required; profile; voltage power; flow rates; flow rate; receiving means; power supplies; electro-osmotic flow; liquid delivery; electro-osmotically driven; /204/
Citation Formats
Rakestraw, David J, Anex, Deon S, Yan, Chao, Dadoo, Rajeev, and Zare, Richard N. Electro-osmotically driven liquid delivery method and apparatus. United States: N. p., 1999.
Web.
Rakestraw, David J, Anex, Deon S, Yan, Chao, Dadoo, Rajeev, & Zare, Richard N. Electro-osmotically driven liquid delivery method and apparatus. United States.
Rakestraw, David J, Anex, Deon S, Yan, Chao, Dadoo, Rajeev, and Zare, Richard N. Fri .
"Electro-osmotically driven liquid delivery method and apparatus". United States. https://www.osti.gov/servlets/purl/872464.
@article{osti_872464,
title = {Electro-osmotically driven liquid delivery method and apparatus},
author = {Rakestraw, David J and Anex, Deon S and Yan, Chao and Dadoo, Rajeev and Zare, Richard N},
abstractNote = {Method and apparatus for controlling precisely the composition and delivery of liquid at sub-.mu.L/min flow rate. One embodiment of such a delivery system is an electro-osmotically driven gradient flow delivery system that generates dynamic gradient flows with sub-.mu.L/min flow rates by merging a plurality of electro-osmotic flows. These flows are delivered by a plurality of delivery arms attached to a mixing connector, where they mix and then flow into a receiving means, preferably a column. Each inlet of the plurality of delivery arms is placed in a corresponding solution reservoir. A plurality of independent programmable high-voltage power supplies is used to apply a voltage program to each of the plurality of solution reservoirs to regulate the electro-osmotic flow in each delivery arm. The electro-osmotic flow rates in the delivery arms are changed with time according to each voltage program to deliver the required gradient profile to the column.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}