Fiber optic D dimer biosensor

Glass, Robert S; Grant, Sheila A

Title: Fiber optic D dimer biosensor

Abstract

A fiber optic sensor for D dimer (a fibrinolytic product) can be used in vivo (e.g., in catheter-based procedures) for the diagnosis and treatment of stroke-related conditions in humans. Stroke is the third leading cause of death in the United States. It has been estimated that strokes and stroke-related disorders cost Americans between $15-30 billion annually. Relatively recently, new medical procedures have been developed for the treatment of stroke. These endovascular procedures rely upon the use of microcatheters. These procedures could be facilitated with this sensor for D dimer integrated with a microcatheter for the diagnosis of clot type, and as an indicator of the effectiveness, or end-point of thrombolytic therapy.

Inventors:

Glass, Robert S ^[1]; Grant, Sheila A ^[2]

Livermore, CA
Pleasanton, CA

Issue Date:: 1999-01-01

Research Org.:: Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

OSTI Identifier:: 872449

Patent Number(s):: 5938595

Assignee:: Regents of University of California (Oakland, CA)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/86 - involving blood coagulating time {or factors, or their receptors}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B5/0084 - {for introduction into the body, e.g. by catheters

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DOE Contract Number:: W-7405-ENG-48

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: fiber; optic; dimer; biosensor; sensor; fibrinolytic; product; vivo; catheter-based; procedures; diagnosis; treatment; stroke-related; conditions; humans; stroke; third; leading; death; united; estimated; strokes; disorders; cost; americans; $15-30; billion; annually; relatively; recently; medical; developed; endovascular; rely; microcatheters; facilitated; integrated; microcatheter; clot; type; indicator; effectiveness; end-point; thrombolytic; therapy; medical procedures; fiber optic; optic sensor; stroke-related conditions; /600/356/

Citation Formats


                    Glass, Robert S, and Grant, Sheila A. Fiber optic D dimer biosensor.  United States: N. p., 1999. 
        Web.

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                    Glass, Robert S, & Grant, Sheila A. Fiber optic D dimer biosensor.  United States.

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                    Glass, Robert S, and Grant, Sheila A. Fri .  
        "Fiber optic D dimer biosensor".  United States.  https://www.osti.gov/servlets/purl/872449.

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@article{osti_872449,

  title        = {Fiber optic D dimer biosensor},

  author       = {Glass, Robert S and Grant, Sheila A},

  abstractNote = {A fiber optic sensor for D dimer (a fibrinolytic product) can be used in vivo (e.g., in catheter-based procedures) for the diagnosis and treatment of stroke-related conditions in humans. Stroke is the third leading cause of death in the United States. It has been estimated that strokes and stroke-related disorders cost Americans between $15-30 billion annually. Relatively recently, new medical procedures have been developed for the treatment of stroke. These endovascular procedures rely upon the use of microcatheters. These procedures could be facilitated with this sensor for D dimer integrated with a microcatheter for the diagnosis of clot type, and as an indicator of the effectiveness, or end-point of thrombolytic therapy.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1999},

  month        = {1}

}

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Works referenced in this record:

Endoscopic system for simultaneous visual examination and electronic detection of fluorescence
journal, October 1980

Kinsey, J. H.; Cortese, D. A.
Review of Scientific Instruments, Vol. 51, Issue 10
https://doi.org/10.1063/1.1136099

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Title: Fiber optic D dimer biosensor

Abstract

Citation Formats

Endoscopic system for simultaneous visual examination and electronic detection of fluorescence journal, October 1980

Endoscopic system for simultaneous visual examination and electronic detection of fluorescence
journal, October 1980