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Title: Mutation assays involving blood cells that metabolize toxic substances

Abstract

The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics.

Inventors:
 [1];  [2]
  1. (Marblehead, MA)
  2. (Winchester, MA)
Issue Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA
OSTI Identifier:
872440
Patent Number(s):
5935829
Assignee:
Massachusetts Institute of Technology (Cambridge, MA) SNL
DOE Contract Number:  
AC04-76
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
mutation; assays; involving; blood; cells; metabolize; toxic; substances; pertains; line; human; levels; oxidative; activity; oxygenase; oxidase; peroxidase; hydroxylase; grow; suspension; culture; useful; determine; mutagenicity; xenobiotic; metabolized; mutagenic; similar; characteristics; blood cells; blood cell; mutation assays; human blood; metabolize toxic; oxidative activity; suspension culture; toxic substances; hydroxylase activity; cells grow; assays involving; involving blood; /435/

Citation Formats

Crespi, Charles L., and Thilly, William G. Mutation assays involving blood cells that metabolize toxic substances. United States: N. p., 1999. Web.
Crespi, Charles L., & Thilly, William G. Mutation assays involving blood cells that metabolize toxic substances. United States.
Crespi, Charles L., and Thilly, William G. Fri . "Mutation assays involving blood cells that metabolize toxic substances". United States. https://www.osti.gov/servlets/purl/872440.
@article{osti_872440,
title = {Mutation assays involving blood cells that metabolize toxic substances},
author = {Crespi, Charles L. and Thilly, William G.},
abstractNote = {The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

Patent:

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