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Title: Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites

Abstract

Halogenated naphthyl methoxy piperidines having a strong affinity for the serotonin transporter are disclosed. Those compounds can be labeled with positron-emitting and/or gamma emitting halogen isotopes by a late step synthesis that maximizes the useable lifeterm of the label. The labeled compounds are useful for localizing serotonin transporter sites by positron emission tomography and/or single photon emission computed tomography.

Inventors:
 [1];  [2]
  1. (Atlanta, GA)
  2. (Lithonia, GA)
Issue Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN
OSTI Identifier:
872369
Patent Number(s):
5919797
Assignee:
Emory University (Atlanta, GA) ORNL
DOE Contract Number:  
FG05-93ER61737
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
halogenated; naphthyl; methoxy; piperidines; mapping; serotonin; transporter; sites; strong; affinity; disclosed; compounds; labeled; positron-emitting; gamma; emitting; halogen; isotopes; step; synthesis; maximizes; useable; lifeterm; label; useful; localizing; positron; emission; tomography; single; photon; computed; computed tomography; serotonin transporter; emission tomography; positron emission; photon emission; single photon; labeled compounds; emission computed; methoxy piperidines; naphthyl methoxy; halogen isotopes; halogenated naphthyl; gamma emitting; /514/424/999/

Citation Formats

Goodman, Mark M., and Faraj, Bahjat. Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites. United States: N. p., 1999. Web.
Goodman, Mark M., & Faraj, Bahjat. Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites. United States.
Goodman, Mark M., and Faraj, Bahjat. Fri . "Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites". United States. https://www.osti.gov/servlets/purl/872369.
@article{osti_872369,
title = {Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites},
author = {Goodman, Mark M. and Faraj, Bahjat},
abstractNote = {Halogenated naphthyl methoxy piperidines having a strong affinity for the serotonin transporter are disclosed. Those compounds can be labeled with positron-emitting and/or gamma emitting halogen isotopes by a late step synthesis that maximizes the useable lifeterm of the label. The labeled compounds are useful for localizing serotonin transporter sites by positron emission tomography and/or single photon emission computed tomography.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

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