Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites
Abstract
Halogenated naphthyl methoxy piperidines having a strong affinity for the serotonin transporter are disclosed. Those compounds can be labeled with positron-emitting and/or gamma emitting halogen isotopes by a late step synthesis that maximizes the useable lifeterm of the label. The labeled compounds are useful for localizing serotonin transporter sites by positron emission tomography and/or single photon emission computed tomography.
- Inventors:
-
- Atlanta, GA
- Lithonia, GA
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- OSTI Identifier:
- 872369
- Patent Number(s):
- 5919797
- Assignee:
- Emory University (Atlanta, GA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
- DOE Contract Number:
- FG05-93ER61737
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- halogenated; naphthyl; methoxy; piperidines; mapping; serotonin; transporter; sites; strong; affinity; disclosed; compounds; labeled; positron-emitting; gamma; emitting; halogen; isotopes; step; synthesis; maximizes; useable; lifeterm; label; useful; localizing; positron; emission; tomography; single; photon; computed; computed tomography; serotonin transporter; emission tomography; positron emission; photon emission; single photon; labeled compounds; emission computed; methoxy piperidines; naphthyl methoxy; halogen isotopes; halogenated naphthyl; gamma emitting; /514/424/999/
Citation Formats
Goodman, Mark M, and Faraj, Bahjat. Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites. United States: N. p., 1999.
Web.
Goodman, Mark M, & Faraj, Bahjat. Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites. United States.
Goodman, Mark M, and Faraj, Bahjat. Fri .
"Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites". United States. https://www.osti.gov/servlets/purl/872369.
@article{osti_872369,
title = {Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites},
author = {Goodman, Mark M and Faraj, Bahjat},
abstractNote = {Halogenated naphthyl methoxy piperidines having a strong affinity for the serotonin transporter are disclosed. Those compounds can be labeled with positron-emitting and/or gamma emitting halogen isotopes by a late step synthesis that maximizes the useable lifeterm of the label. The labeled compounds are useful for localizing serotonin transporter sites by positron emission tomography and/or single photon emission computed tomography.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}
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