Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry

Yeung, Edward S; Chang, Yu-chen

Title: Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry

Abstract

The present invention provides a laser-induced vaporization and ionization interface for directly coupling microscale separation processes to a mass spectrometer. Vaporization and ionization of the separated analytes are facilitated by the addition of a light-absorbing component to the separation buffer or solvent.

Inventors:

Yeung, Edward S ^[1]; Chang, Yu-chen ^[2]

Ames, IA
Taichung Hsien, TW

Issue Date:: 1999-01-01

Research Org.:: Ames Laboratory (AMES), Ames, IA; Iowa State Univ., Ames, IA (United States)

OSTI Identifier:: 872359

Patent Number(s):: 5917185

Application Number:: 08/882,855

Assignee:: Iowa State University Research Foundation, Inc. (Ames, IA)

Patent Classifications (CPCs):: H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

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H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
H01J49/0404 - {Capillaries used for transferring samples or ions
H01J49/0431 - {for liquid samples
H01J49/164 - {Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]

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DOE Contract Number:: W-7405-ENG-82

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: laser; vaporization; ionization; interface; coupling; microscale; separation; techniques; mass; spectrometry; provides; laser-induced; directly; processes; spectrometer; separated; analytes; facilitated; addition; light-absorbing; component; buffer; solvent; separation processes; separation techniques; separation process; mass spectrometer; mass spectrometry; absorbing component; microscale separation; ionization interface; separation technique; scale separation; directly coupling; laser vaporization; coupling microscale; /250/

Citation Formats


                    Yeung, Edward S, and Chang, Yu-chen. Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry.  United States: N. p., 1999. 
        Web.

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                    Yeung, Edward S, & Chang, Yu-chen. Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry.  United States.

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                    Yeung, Edward S, and Chang, Yu-chen. Fri .  
        "Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry".  United States.  https://www.osti.gov/servlets/purl/872359.

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@article{osti_872359,

  title        = {Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry},

  author       = {Yeung, Edward S and Chang, Yu-chen},

  abstractNote = {The present invention provides a laser-induced vaporization and ionization interface for directly coupling microscale separation processes to a mass spectrometer. Vaporization and ionization of the separated analytes are facilitated by the addition of a light-absorbing component to the separation buffer or solvent.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1999},

  month        = {1}

}

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Similar Records

Title: Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry

Abstract

Citation Formats

Continuous-flow matrix-assisted laser desorption ionization mass spectrometry journal, February 1993

Mechanism of electrospray mass spectrometry. Electrospray as an electrolysis cell journal, October 1991

Aerosol MALDI with a Reflectron Time-of-Flight Mass Spectrometer journal, January 1996

Capillary zone electrophoresis-mass spectrometry using a coaxial continuous-flow fast atom bombardment interface journal, September 1990

Quantitative Capillary Electrophoresis-Ion Spray Mass Spectrometry on a Benchtop Ion Trap for the Determination of Isoquinoline Alkaloids journal, July 1994

On-line mass spectrometric detection for capillary zone electrophoresis journal, April 1987

Performance of a liquid-junction interface for capillary electrophoresis mass spectrometry using continuous-flow fast-atom bombardment journal, October 1989

Electrospray ion source. Another variation on the free-jet theme journal, September 1984

Capillary zone electrophoresis: its applicability and potential in biochemical analysis journal, September 1991

On-line capillary electrophoresis with Fourier transform ion cyclotron resonance mass spectrometry journal, July 1993

Pulsed sample introduction interface for combining flow injection analysis with multiphoton ionization time-of-flight mass spectrometry journal, April 1992

Liquid sample introduction for matrix-assisted laser desorption ionization journal, September 1993

Capillary electrophoresis journal, June 1992

Liquid Chromatography/Time-of-Flight Mass Spectrometry with a Pulsed Sample Introduction Interface journal, November 1994

Capillary Electrophoresis journal, February 1989

Online Time-of-Flight Mass Spectrometric Analysis of Peptides Separated by Capillary Electrophoresis journal, November 1994

Atmospheric pressure ionization mass spectrometry. Detection for the separation sciences. journal, July 1990

Capillary electrophoresis journal, June 1990

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Coupling capillary zone electrophoresis and continuous- flow fast atom bombardment mass spectrometry for the analysis of peptide mixtures journal, January 1989

A continuous-flow sample probe for fast atom bombardment mass spectrometry journal, December 1986

Liquid chromatography-time-of-flight mass spectrometry with continuous-flow matrix-assisted laser desorption ionization journal, September 1995

Continuous-flow matrix-assisted laser desorption ionization mass spectrometry
journal, February 1993

Mechanism of electrospray mass spectrometry. Electrospray as an electrolysis cell
journal, October 1991

Aerosol MALDI with a Reflectron Time-of-Flight Mass Spectrometer
journal, January 1996

Capillary zone electrophoresis-mass spectrometry using a coaxial continuous-flow fast atom bombardment interface
journal, September 1990

Quantitative Capillary Electrophoresis-Ion Spray Mass Spectrometry on a Benchtop Ion Trap for the Determination of Isoquinoline Alkaloids
journal, July 1994

On-line mass spectrometric detection for capillary zone electrophoresis
journal, April 1987

Performance of a liquid-junction interface for capillary electrophoresis mass spectrometry using continuous-flow fast-atom bombardment
journal, October 1989

Electrospray ion source. Another variation on the free-jet theme
journal, September 1984

Capillary zone electrophoresis: its applicability and potential in biochemical analysis
journal, September 1991

On-line capillary electrophoresis with Fourier transform ion cyclotron resonance mass spectrometry
journal, July 1993

Pulsed sample introduction interface for combining flow injection analysis with multiphoton ionization time-of-flight mass spectrometry
journal, April 1992

Liquid sample introduction for matrix-assisted laser desorption ionization
journal, September 1993

Capillary electrophoresis
journal, June 1992

Liquid Chromatography/Time-of-Flight Mass Spectrometry with a Pulsed Sample Introduction Interface
journal, November 1994

Capillary Electrophoresis
journal, February 1989

Online Time-of-Flight Mass Spectrometric Analysis of Peptides Separated by Capillary Electrophoresis
journal, November 1994

Atmospheric pressure ionization mass spectrometry. Detection for the separation sciences.
journal, July 1990

Capillary electrophoresis
journal, June 1990

Capillary electrophoresis
journal, November 1990

Coupling capillary zone electrophoresis and continuous- flow fast atom bombardment mass spectrometry for the analysis of peptide mixtures
journal, January 1989

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journal, December 1986

Liquid chromatography-time-of-flight mass spectrometry with continuous-flow matrix-assisted laser desorption ionization
journal, September 1995