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Title: Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids

Abstract

A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid and includes a functional group which reacts with the target nucleic acid to render the target nucleic acid inactive or nonfunctional.

Inventors:
 [1];  [2]
  1. Baltimore, MD
  2. Lutherville, MD
Issue Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
872330
Patent Number(s):
5912339
Application Number:
08/342005
Assignee:
Johns Hopkins University (Baltimore, MD)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
FG02-88ER60636
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
oligonucleoside; alkyl; arylphosphonate; derivatives; capable; crosslinking; cleaving; nucleic; acids; composition; inactivating; target; acid; comprises; analogue; complementary; sequence; functional; reacts; render; inactive; nonfunctional; nucleic acid; nucleic acids; target nucleic; oligonucleoside alkyl; target nuclei; /999/435/

Citation Formats

Miller, Paul S, and Ts'o, Paul O.P.. Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids. United States: N. p., 1999. Web.
Miller, Paul S, & Ts'o, Paul O.P.. Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids. United States.
Miller, Paul S, and Ts'o, Paul O.P.. Tue . "Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids". United States. https://www.osti.gov/servlets/purl/872330.
@article{osti_872330,
title = {Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids},
author = {Miller, Paul S and Ts'o, Paul O.P.},
abstractNote = {A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid and includes a functional group which reacts with the target nucleic acid to render the target nucleic acid inactive or nonfunctional.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {6}
}

Patent:

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