Title: Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids

Abstract

A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid and includes a functional group which reacts with the target nucleic acid to render the target nucleic acid inactive or nonfunctional.

Inventors:

Miller, Paul S ^[1]; Ts'o, Paul O.P. ^[2]

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1. Baltimore, MD
2. Lutherville, MD

Issue Date:

1999-06-15

Research Org.:

Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

872330

Patent Number(s):

5912339

Application Number:

08/342005

Assignee:

Johns Hopkins University (Baltimore, MD)

Patent Classifications (CPCs):

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS

C07H21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q2523/113 - Denaturating agents
C12Q1/68 - involving nucleic acids

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DOE Contract Number:  

FG02-88ER60636

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

oligonucleoside; alkyl; arylphosphonate; derivatives; capable; crosslinking; cleaving; nucleic; acids; composition; inactivating; target; acid; comprises; analogue; complementary; sequence; functional; reacts; render; inactive; nonfunctional; nucleic acid; nucleic acids; target nucleic; oligonucleoside alkyl; target nuclei; /999/435/