5'to 3' nucleic acid synthesis using 3'-photoremovable protecting group
Abstract
The present invention relates, in general, to a method of synthesizing a nucleic acid, and, in particular, to a method of effecting 5' to 3' nucleic acid synthesis. The method can be used to prepare arrays of oligomers bound to a support via their 5' end. The invention also relates to a method of effecting mutation analysis using such arrays. The invention further relates to compounds and compositions suitable for use in such methods.
- Inventors:
-
- Houston, TX
- Durham, NC
- Issue Date:
- Research Org.:
- Duke University (Durham, NC)
- OSTI Identifier:
- 872315
- Patent Number(s):
- 5908926
- Assignee:
- Duke University (Durham, NC)
- Patent Classifications (CPCs):
-
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02P - CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
- DOE Contract Number:
- FG05-92ER61388
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- nucleic; acid; synthesis; -photoremovable; protecting; relates; method; synthesizing; particular; effecting; prepare; arrays; oligomers; bound; support; via; mutation; analysis; compounds; compositions; suitable; methods; nucleic acid; compositions suitable; acid synthesis; /999/
Citation Formats
Pirrung, Michael C, Shuey, Steven W, and Bradley, Jean-Claude. 5'to 3' nucleic acid synthesis using 3'-photoremovable protecting group. United States: N. p., 1999.
Web.
Pirrung, Michael C, Shuey, Steven W, & Bradley, Jean-Claude. 5'to 3' nucleic acid synthesis using 3'-photoremovable protecting group. United States.
Pirrung, Michael C, Shuey, Steven W, and Bradley, Jean-Claude. Fri .
"5'to 3' nucleic acid synthesis using 3'-photoremovable protecting group". United States. https://www.osti.gov/servlets/purl/872315.
@article{osti_872315,
title = {5'to 3' nucleic acid synthesis using 3'-photoremovable protecting group},
author = {Pirrung, Michael C and Shuey, Steven W and Bradley, Jean-Claude},
abstractNote = {The present invention relates, in general, to a method of synthesizing a nucleic acid, and, in particular, to a method of effecting 5' to 3' nucleic acid synthesis. The method can be used to prepare arrays of oligomers bound to a support via their 5' end. The invention also relates to a method of effecting mutation analysis using such arrays. The invention further relates to compounds and compositions suitable for use in such methods.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}
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