Method for quantifying optical properties of the human lens

Bigio, Irving J; Zuclich, Joseph A; Shimada, Tsutomu; Strobl, Karlheinz

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Title: Method for quantifying optical properties of the human lens

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Abstract

Method for quantifying optical properties of the human lens. The present invention includes the application of fiberoptic, OMA-based instrumentation as an in vivo diagnostic tool for the human ocular lens. Rapid, noninvasive and comprehensive assessment of the optical characteristics of a lens using very modest levels of exciting light are described. Typically, the backscatter and fluorescence spectra (from about 300- to 900-nm) elicited by each of several exciting wavelengths (from about 300- to 600-nm) are collected within a few seconds. The resulting optical signature of individual lenses is then used to assess the overall optical quality of the lens by comparing the results with a database of similar measurements obtained from a reference set of normal human lenses having various ages. Several metrics have been identified which gauge the optical quality of a given lens relative to the norm for the subject's chronological age. These metrics may also serve to document accelerated optical aging and/or as early indicators of cataract or other disease processes.

Inventors:

Loree, deceased, Thomas R. ^[1]; Bigio, Irving J ^[2]; Zuclich, Joseph A ^[3]; Shimada, Tsutomu ^[2]; Strobl, Karlheinz ^[4]

(late of Albuquerque, NM)
Los Alamos, NM
San Antonio, TX
Fiskdale, MA

Issue Date:: 1999-01-01

Research Org.:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

OSTI Identifier:: 872253

Patent Number(s):: 5894340

Assignee:: Regents of University of California (Los Alamos, NM)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
A61B3/1176 - {for determining lens opacity, e.g. cataract}

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DOE Contract Number:: W-7405-ENG-36

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: method; quantifying; optical; properties; human; lens; application; fiberoptic; oma-based; instrumentation; vivo; diagnostic; tool; ocular; rapid; noninvasive; comprehensive; assessment; characteristics; modest; levels; exciting; light; described; typically; backscatter; fluorescence; spectra; 300-; 900-nm; elicited; wavelengths; 600-nm; collected; resulting; signature; individual; lenses; assess; overall; quality; comparing; results; database; similar; measurements; obtained; reference; set; normal; various; ages; metrics; identified; gauge; relative; norm; subject; chronological; age; serve; document; accelerated; aging; indicators; cataract; disease; processes; optical properties; optical quality; measurements obtained; normal human; overall optical; exciting light; quantifying optical; diagnostic tool; human lens; ocular lens; /351/

Citation Formats


                    Loree, deceased, Thomas R., Bigio, Irving J, Zuclich, Joseph A, Shimada, Tsutomu, and Strobl, Karlheinz. Method for quantifying optical properties of the human lens.  United States: N. p., 1999. 
        Web.

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                    Loree, deceased, Thomas R., Bigio, Irving J, Zuclich, Joseph A, Shimada, Tsutomu, & Strobl, Karlheinz. Method for quantifying optical properties of the human lens.  United States.

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                    Loree, deceased, Thomas R., Bigio, Irving J, Zuclich, Joseph A, Shimada, Tsutomu, and Strobl, Karlheinz. Fri .  
        "Method for quantifying optical properties of the human lens".  United States.  https://www.osti.gov/servlets/purl/872253.

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@article{osti_872253,

  title        = {Method for quantifying optical properties of the human lens},

  author       = {Loree, deceased, Thomas R. and Bigio, Irving J and Zuclich, Joseph A and Shimada, Tsutomu and Strobl, Karlheinz},

  abstractNote = {Method for quantifying optical properties of the human lens. The present invention includes the application of fiberoptic, OMA-based instrumentation as an in vivo diagnostic tool for the human ocular lens. Rapid, noninvasive and comprehensive assessment of the optical characteristics of a lens using very modest levels of exciting light are described. Typically, the backscatter and fluorescence spectra (from about 300- to 900-nm) elicited by each of several exciting wavelengths (from about 300- to 600-nm) are collected within a few seconds. The resulting optical signature of individual lenses is then used to assess the overall optical quality of the lens by comparing the results with a database of similar measurements obtained from a reference set of normal human lenses having various ages. Several metrics have been identified which gauge the optical quality of a given lens relative to the norm for the subject's chronological age. These metrics may also serve to document accelerated optical aging and/or as early indicators of cataract or other disease processes.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1999},

  month        = {1}

}

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