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Title: Method for quantifying optical properties of the human lens

Abstract

Method for quantifying optical properties of the human lens. The present invention includes the application of fiberoptic, OMA-based instrumentation as an in vivo diagnostic tool for the human ocular lens. Rapid, noninvasive and comprehensive assessment of the optical characteristics of a lens using very modest levels of exciting light are described. Typically, the backscatter and fluorescence spectra (from about 300- to 900-nm) elicited by each of several exciting wavelengths (from about 300- to 600-nm) are collected within a few seconds. The resulting optical signature of individual lenses is then used to assess the overall optical quality of the lens by comparing the results with a database of similar measurements obtained from a reference set of normal human lenses having various ages. Several metrics have been identified which gauge the optical quality of a given lens relative to the norm for the subject's chronological age. These metrics may also serve to document accelerated optical aging and/or as early indicators of cataract or other disease processes.

Inventors:
 [1];  [2];  [3];  [2];  [4]
  1. (late of Albuquerque, NM)
  2. Los Alamos, NM
  3. San Antonio, TX
  4. Fiskdale, MA
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
OSTI Identifier:
872253
Patent Number(s):
5894340
Assignee:
Regents of University of California (Los Alamos, NM)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; quantifying; optical; properties; human; lens; application; fiberoptic; oma-based; instrumentation; vivo; diagnostic; tool; ocular; rapid; noninvasive; comprehensive; assessment; characteristics; modest; levels; exciting; light; described; typically; backscatter; fluorescence; spectra; 300-; 900-nm; elicited; wavelengths; 600-nm; collected; resulting; signature; individual; lenses; assess; overall; quality; comparing; results; database; similar; measurements; obtained; reference; set; normal; various; ages; metrics; identified; gauge; relative; norm; subject; chronological; age; serve; document; accelerated; aging; indicators; cataract; disease; processes; optical properties; optical quality; measurements obtained; normal human; overall optical; exciting light; quantifying optical; diagnostic tool; human lens; ocular lens; /351/

Citation Formats

Loree, deceased, Thomas R., Bigio, Irving J, Zuclich, Joseph A, Shimada, Tsutomu, and Strobl, Karlheinz. Method for quantifying optical properties of the human lens. United States: N. p., 1999. Web.
Loree, deceased, Thomas R., Bigio, Irving J, Zuclich, Joseph A, Shimada, Tsutomu, & Strobl, Karlheinz. Method for quantifying optical properties of the human lens. United States.
Loree, deceased, Thomas R., Bigio, Irving J, Zuclich, Joseph A, Shimada, Tsutomu, and Strobl, Karlheinz. Fri . "Method for quantifying optical properties of the human lens". United States. https://www.osti.gov/servlets/purl/872253.
@article{osti_872253,
title = {Method for quantifying optical properties of the human lens},
author = {Loree, deceased, Thomas R. and Bigio, Irving J and Zuclich, Joseph A and Shimada, Tsutomu and Strobl, Karlheinz},
abstractNote = {Method for quantifying optical properties of the human lens. The present invention includes the application of fiberoptic, OMA-based instrumentation as an in vivo diagnostic tool for the human ocular lens. Rapid, noninvasive and comprehensive assessment of the optical characteristics of a lens using very modest levels of exciting light are described. Typically, the backscatter and fluorescence spectra (from about 300- to 900-nm) elicited by each of several exciting wavelengths (from about 300- to 600-nm) are collected within a few seconds. The resulting optical signature of individual lenses is then used to assess the overall optical quality of the lens by comparing the results with a database of similar measurements obtained from a reference set of normal human lenses having various ages. Several metrics have been identified which gauge the optical quality of a given lens relative to the norm for the subject's chronological age. These metrics may also serve to document accelerated optical aging and/or as early indicators of cataract or other disease processes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

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