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Title: Human dopamine receptor and its uses

Abstract

The present invention is directed toward the isolation, characterization and pharmacological use of the human D4 dopamine receptor. The nucleotide sequence of the gene corresponding to this receptor and alleleic variant thereof are provided by the invention. The invention also includes recombinant eukaryotic expression constructs capable of expressing the human D4 dopamine receptor in cultures of transformed eukaryotic cells. The invention provides cultures of transformed eukaryotic cells which synthesize the human D4 dopamine receptor, and methods for characterizing novel psychotropic compounds using such cultures.

Inventors:
 [1];  [2]
  1. Portland, OR
  2. Toronto, CA
Issue Date:
Research Org.:
Battelle Memorial Institute, Columbus, OH (United States)
OSTI Identifier:
872197
Patent Number(s):
5883226
Assignee:
State of Oregon (Portland, OR)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
human; dopamine; receptor; directed; isolation; characterization; pharmacological; d4; nucleotide; sequence; corresponding; alleleic; variant; provided; recombinant; eukaryotic; expression; constructs; capable; expressing; cultures; transformed; cells; provides; synthesize; methods; characterizing; novel; psychotropic; compounds; nucleotide sequence; dopamine receptor; expression constructs; /530/

Citation Formats

Civelli, Olivier, and Van Tol, Hubert Henri-Marie. Human dopamine receptor and its uses. United States: N. p., 1999. Web.
Civelli, Olivier, & Van Tol, Hubert Henri-Marie. Human dopamine receptor and its uses. United States.
Civelli, Olivier, and Van Tol, Hubert Henri-Marie. Fri . "Human dopamine receptor and its uses". United States. https://www.osti.gov/servlets/purl/872197.
@article{osti_872197,
title = {Human dopamine receptor and its uses},
author = {Civelli, Olivier and Van Tol, Hubert Henri-Marie},
abstractNote = {The present invention is directed toward the isolation, characterization and pharmacological use of the human D4 dopamine receptor. The nucleotide sequence of the gene corresponding to this receptor and alleleic variant thereof are provided by the invention. The invention also includes recombinant eukaryotic expression constructs capable of expressing the human D4 dopamine receptor in cultures of transformed eukaryotic cells. The invention provides cultures of transformed eukaryotic cells which synthesize the human D4 dopamine receptor, and methods for characterizing novel psychotropic compounds using such cultures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

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Works referenced in this record:

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