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Title: Microinjector for blasocysts

Abstract

An electromechanical device for driving the tip of a microinjection cannula, or needle, through the outer barrier of a blastocyst, cell, or cell nucleus for the injection of cells or other bioactive materials. Either a flexible frame or a ram moving within a base member is employed. Cannula motion is achieved by means of a piezoelectric stack and spring return system. The thrust motion over a predetermined microscopic distance is achieved without cannula setback prior to the thrust movement. Instead of specially prepared beveled and tipped needles, standard unimproved cannulas or needles can be used.

Inventors:
 [1];  [2];  [3];  [4];  [5]
+ Show Inventor Affiliations
  1. Knoxville, TN
  2. Beechwood, OH
  3. Loudon, TN
  4. Oak Ridge, TN
  5. Clinton, TN
Issue Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
OSTI Identifier:
872171
Patent Number(s):
5877008
Assignee:
Lockheed Martin Energy Research Corporation (Oak Ridge, TN)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12M - APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
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DOE Contract Number:  
AC05-96OR22464
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
microinjector; blasocysts; electromechanical; device; driving; tip; microinjection; cannula; needle; outer; barrier; blastocyst; cell; nucleus; injection; cells; bioactive; materials; flexible; frame; moving; base; employed; motion; achieved; means; piezoelectric; stack; spring; return; thrust; predetermined; microscopic; distance; setback; prior; movement; specially; prepared; beveled; tipped; needles; standard; unimproved; cannulas; active material; active materials; mechanical device; flexible frame; spring return; specially prepared; /435/73/

Citation Formats

Remenyik, Carl J, Woychik, Richard P, Patek, David R, Hawk, James A, and Turner, John C. Microinjector for blasocysts. United States: N. p., 1999. Web.
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Remenyik, Carl J, Woychik, Richard P, Patek, David R, Hawk, James A, & Turner, John C. Microinjector for blasocysts. United States.
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Remenyik, Carl J, Woychik, Richard P, Patek, David R, Hawk, James A, and Turner, John C. Fri . "Microinjector for blasocysts". United States. https://www.osti.gov/servlets/purl/872171.
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@article{osti_872171,
title = {Microinjector for blasocysts},
author = {Remenyik, Carl J and Woychik, Richard P and Patek, David R and Hawk, James A and Turner, John C},
abstractNote = {An electromechanical device for driving the tip of a microinjection cannula, or needle, through the outer barrier of a blastocyst, cell, or cell nucleus for the injection of cells or other bioactive materials. Either a flexible frame or a ram moving within a base member is employed. Cannula motion is achieved by means of a piezoelectric stack and spring return system. The thrust motion over a predetermined microscopic distance is achieved without cannula setback prior to the thrust movement. Instead of specially prepared beveled and tipped needles, standard unimproved cannulas or needles can be used.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}
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