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Title: Method for the production of dicarboxylic acids

Abstract

The present invention is an economical fermentation method for the production of carboxylic acids comprising the steps of a) inoculating a medium having a carbon source with a carboxylic acid-producing organism; b) incubating the carboxylic acid-producing organism in an aerobic atmosphere to promote rapid growth of the organism thereby increasing the biomass of the organism; c) controllably releasing oxygen to maintain the aerobic atmosphere; d) controllably feeding the organism having increased biomass with a solution containing the carbon source to maintain the concentration of the carbon source within the medium of about 0.5 g/L up to about 1 g/L; e) depriving the aerobic atmosphere of oxygen to produce an anaerobic atmosphere to cause the organism to undergo anaerobic metabolism; f) controllably feeding the organism having increased biomass a solution containing the carbon source to maintain the concentration of the carbon source within the medium of .gtoreq.1 g/L; and g) converting the carbon source to carboxylic acids using the anaerobic metabolism of the organism.

Inventors:
 [1];  [2];  [3];  [4]
+ Show Inventor Affiliations
  1. Knoxville, TN
  2. Warrenville, IL
  3. Plainfield, IL
  4. Woodridge, IL
Issue Date:
Research Org.:
Argonne National Laboratory (ANL), Argonne, IL (United States); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
872139
Patent Number(s):
5869301
Assignee:
Lockhead Martin Energy Research Corporation (Oak Ridge, TN)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
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DOE Contract Number:  
W-31109-ENG-38; AC05-96OR22464
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; production; dicarboxylic; acids; economical; fermentation; carboxylic; comprising; steps; inoculating; medium; carbon; source; acid-producing; organism; incubating; aerobic; atmosphere; promote; rapid; growth; increasing; biomass; controllably; releasing; oxygen; maintain; feeding; increased; solution; containing; concentration; depriving; produce; anaerobic; undergo; metabolism; gtoreq; converting; solution containing; carbon source; carboxylic acids; carboxylic acid; releasing oxygen; dicarboxylic acid; fermentation method; dicarboxylic acids; /435/

Citation Formats

Nghiem, Nhuan Phu, Donnelly, Mark, Millard, Cynthia S, and Stols, Lucy. Method for the production of dicarboxylic acids. United States: N. p., 1999. Web.
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Nghiem, Nhuan Phu, Donnelly, Mark, Millard, Cynthia S, & Stols, Lucy. Method for the production of dicarboxylic acids. United States.
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Nghiem, Nhuan Phu, Donnelly, Mark, Millard, Cynthia S, and Stols, Lucy. Fri . "Method for the production of dicarboxylic acids". United States. https://www.osti.gov/servlets/purl/872139.
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@article{osti_872139,
title = {Method for the production of dicarboxylic acids},
author = {Nghiem, Nhuan Phu and Donnelly, Mark and Millard, Cynthia S and Stols, Lucy},
abstractNote = {The present invention is an economical fermentation method for the production of carboxylic acids comprising the steps of a) inoculating a medium having a carbon source with a carboxylic acid-producing organism; b) incubating the carboxylic acid-producing organism in an aerobic atmosphere to promote rapid growth of the organism thereby increasing the biomass of the organism; c) controllably releasing oxygen to maintain the aerobic atmosphere; d) controllably feeding the organism having increased biomass with a solution containing the carbon source to maintain the concentration of the carbon source within the medium of about 0.5 g/L up to about 1 g/L; e) depriving the aerobic atmosphere of oxygen to produce an anaerobic atmosphere to cause the organism to undergo anaerobic metabolism; f) controllably feeding the organism having increased biomass a solution containing the carbon source to maintain the concentration of the carbon source within the medium of .gtoreq.1 g/L; and g) converting the carbon source to carboxylic acids using the anaerobic metabolism of the organism.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}
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Works referenced in this record:

Carbon metabolism regulates expression of the pfl (pyruvate formate-lyase) gene in Escherichia coli.
journal, January 1991

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