skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Crystallization of M-CSF.alpha.

Abstract

The present invention is directed to methods for crystallizing macrophage colony stimulating factor (M-CSF) and to a crystalline M-CSF produced thereby. The present invention is also directed to methods for designing and producing M-CSF agonists and antagonists using information derived from the crystallographic structure of M-CSF. The invention is also directed to methods for screening M-CSF agonists and antagonists. In addition, the present invention is directed to an isolated, purified, soluble and functional M-CSF receptor.

Inventors:
 [1];  [2];  [3];  [4];  [5];  [6];  [6];  [7];  [8]
  1. Mystic, CT
  2. Walnut Creek, CA
  3. Moraga, CA
  4. El Cerrito, CA
  5. San Rafael, CA
  6. Oakland, CA
  7. Martinez, CA
  8. Berkeley, CA
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
872125
Patent Number(s):
5866114
Assignee:
Chiron Corporation (Emeryville, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
crystallization; m-csf; alpha; directed; methods; crystallizing; macrophage; colony; stimulating; factor; crystalline; produced; designing; producing; agonists; antagonists; information; derived; crystallographic; structure; screening; addition; isolated; purified; soluble; functional; receptor; graphic structure; crystallographic structure; information derived; /424/117/530/999/

Citation Formats

Pandit, Jayvardhan, Jancarik, Jarmila, Kim, Sung-Hou, Koths, Kirston, Halenbeck, Robert, Fear, Anna Lisa, Taylor, Eric, Yamamoto, Ralph, and Bohm, Andrew. Crystallization of M-CSF.alpha.. United States: N. p., 1999. Web.
Pandit, Jayvardhan, Jancarik, Jarmila, Kim, Sung-Hou, Koths, Kirston, Halenbeck, Robert, Fear, Anna Lisa, Taylor, Eric, Yamamoto, Ralph, & Bohm, Andrew. Crystallization of M-CSF.alpha.. United States.
Pandit, Jayvardhan, Jancarik, Jarmila, Kim, Sung-Hou, Koths, Kirston, Halenbeck, Robert, Fear, Anna Lisa, Taylor, Eric, Yamamoto, Ralph, and Bohm, Andrew. Fri . "Crystallization of M-CSF.alpha.". United States. https://www.osti.gov/servlets/purl/872125.
@article{osti_872125,
title = {Crystallization of M-CSF.alpha.},
author = {Pandit, Jayvardhan and Jancarik, Jarmila and Kim, Sung-Hou and Koths, Kirston and Halenbeck, Robert and Fear, Anna Lisa and Taylor, Eric and Yamamoto, Ralph and Bohm, Andrew},
abstractNote = {The present invention is directed to methods for crystallizing macrophage colony stimulating factor (M-CSF) and to a crystalline M-CSF produced thereby. The present invention is also directed to methods for designing and producing M-CSF agonists and antagonists using information derived from the crystallographic structure of M-CSF. The invention is also directed to methods for screening M-CSF agonists and antagonists. In addition, the present invention is directed to an isolated, purified, soluble and functional M-CSF receptor.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

Patent:

Save / Share:

Works referenced in this record:

Human CSF-1: gene structure and alternative splicing of mRNA precursors.
journal, September 1987


Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor
journal, November 1992


Crystallization and preliminary X-ray studies of recombinant human granulocyte-macrophage colony stimulating factor
journal, February 1989


Purification of the colony-stimulating factor 1 receptor and demonstration of its tyrosine kinase activity.
journal, March 1987


Inducible production of human macrophage growth factor, CSF-1
journal, September 1986


Sparse matrix sampling: a screening method for crystallization of proteins
journal, August 1991


Crystallization of proteins from polyethylene glycol.
journal, October 1976


Deciphering the message in protein sequences: tolerance to amino acid substitutions
journal, March 1990


Molecular and Biological Properties of Human Macrophage Growth Factor, CSF-1
journal, January 1986


Human macrophage-colony stimulating factor: Alternative RNA and protein processing from a single gene
journal, August 1988