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Title: Process for producing 8-fluoropurines

Abstract

An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F.sub.2 in He or other inert gas.

Inventors:
 [1];  [2];  [2];  [3]
  1. Agoura Hills, CA
  2. Los Angeles, CA
  3. Encino, CA
Issue Date:
Research Org.:
Univ. of California (United States)
OSTI Identifier:
872106
Patent Number(s):
5861503
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
DOE Contract Number:  
FC03-87ER60615
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
process; producing; 8-fluoropurines; efficient; regiocontrolled; approach; synthesis; direct; fluorination; purines; dilute; elemental; fluorine; acetyl; hypofluorite; provided; preferred; embodiment; purine; compound; dissolved; polar; solvent; reacted; mixture; inert; gas; polar solvent; preferred embodiment; inert gas; acetyl hypofluorite; direct fluorination; regiocontrolled approach; purine compound; dilute mixture; elemental fluorine; dilute elemental; /999/

Citation Formats

Barrio, Jorge R, Satyamurthy, Nagichettiar, Namavari, Mohammad, and Phelps, Michael E. Process for producing 8-fluoropurines. United States: N. p., 1999. Web.
Barrio, Jorge R, Satyamurthy, Nagichettiar, Namavari, Mohammad, & Phelps, Michael E. Process for producing 8-fluoropurines. United States.
Barrio, Jorge R, Satyamurthy, Nagichettiar, Namavari, Mohammad, and Phelps, Michael E. Fri . "Process for producing 8-fluoropurines". United States. https://www.osti.gov/servlets/purl/872106.
@article{osti_872106,
title = {Process for producing 8-fluoropurines},
author = {Barrio, Jorge R and Satyamurthy, Nagichettiar and Namavari, Mohammad and Phelps, Michael E},
abstractNote = {An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F.sub.2 in He or other inert gas.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

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