Urea biosensor for hemodialysis monitoring
Abstract
An electrochemical sensor capable of detecting and quantifying urea in fluids resulting from hemodialysis procedures. The sensor is based upon measurement of the pH change produced in an aqueous environment by the products of the enzyme-catalyzed hydrolysis of urea. The sensor may be fabricated using methods amenable to mass fabrication, resulting in low-cost sensors and thus providing the potential for disposable use. In a typical application, the sensor could be used in treatment centers, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. The sensor can also be utilized to allow at-home testing to determine if dialysis was necessary. Such a home monitor is similar, in principle, to devices used for blood glucose testing by diabetics, and would require a blood droplet sample by using a finger prick.
- Inventors:
-
- Livermore, CA
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- OSTI Identifier:
- 872091
- Patent Number(s):
- 5858186
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- urea; biosensor; hemodialysis; monitoring; electrochemical; sensor; capable; detecting; quantifying; fluids; resulting; procedures; based; measurement; ph; change; produced; aqueous; environment; products; enzyme-catalyzed; hydrolysis; fabricated; methods; amenable; mass; fabrication; low-cost; sensors; providing; potential; disposable; typical; application; treatment; centers; conjunction; appropriate; electronics; computer; determine; endpoint; utilized; allow; at-home; testing; dialysis; home; monitor; similar; principle; devices; blood; glucose; diabetics; require; droplet; sample; finger; prick; blood glucose; electrochemical sensor; chemical sensor; typical application; ph change; appropriate electronics; sensor capable; fluids resulting; hemodialysis procedures; /204/435/
Citation Formats
Glass, Robert S. Urea biosensor for hemodialysis monitoring. United States: N. p., 1999.
Web.
Glass, Robert S. Urea biosensor for hemodialysis monitoring. United States.
Glass, Robert S. Fri .
"Urea biosensor for hemodialysis monitoring". United States. https://www.osti.gov/servlets/purl/872091.
@article{osti_872091,
title = {Urea biosensor for hemodialysis monitoring},
author = {Glass, Robert S},
abstractNote = {An electrochemical sensor capable of detecting and quantifying urea in fluids resulting from hemodialysis procedures. The sensor is based upon measurement of the pH change produced in an aqueous environment by the products of the enzyme-catalyzed hydrolysis of urea. The sensor may be fabricated using methods amenable to mass fabrication, resulting in low-cost sensors and thus providing the potential for disposable use. In a typical application, the sensor could be used in treatment centers, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. The sensor can also be utilized to allow at-home testing to determine if dialysis was necessary. Such a home monitor is similar, in principle, to devices used for blood glucose testing by diabetics, and would require a blood droplet sample by using a finger prick.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}
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