skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Urea biosensor for hemodialysis monitoring

Abstract

An electrochemical sensor capable of detecting and quantifying urea in fluids resulting from hemodialysis procedures. The sensor is based upon measurement of the pH change produced in an aqueous environment by the products of the enzyme-catalyzed hydrolysis of urea. The sensor may be fabricated using methods amenable to mass fabrication, resulting in low-cost sensors and thus providing the potential for disposable use. In a typical application, the sensor could be used in treatment centers, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. The sensor can also be utilized to allow at-home testing to determine if dialysis was necessary. Such a home monitor is similar, in principle, to devices used for blood glucose testing by diabetics, and would require a blood droplet sample by using a finger prick.

Inventors:
 [1]
  1. Livermore, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
872091
Patent Number(s):
5858186
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
urea; biosensor; hemodialysis; monitoring; electrochemical; sensor; capable; detecting; quantifying; fluids; resulting; procedures; based; measurement; ph; change; produced; aqueous; environment; products; enzyme-catalyzed; hydrolysis; fabricated; methods; amenable; mass; fabrication; low-cost; sensors; providing; potential; disposable; typical; application; treatment; centers; conjunction; appropriate; electronics; computer; determine; endpoint; utilized; allow; at-home; testing; dialysis; home; monitor; similar; principle; devices; blood; glucose; diabetics; require; droplet; sample; finger; prick; blood glucose; electrochemical sensor; chemical sensor; typical application; ph change; appropriate electronics; sensor capable; fluids resulting; hemodialysis procedures; /204/435/

Citation Formats

Glass, Robert S. Urea biosensor for hemodialysis monitoring. United States: N. p., 1999. Web.
Glass, Robert S. Urea biosensor for hemodialysis monitoring. United States.
Glass, Robert S. Fri . "Urea biosensor for hemodialysis monitoring". United States. https://www.osti.gov/servlets/purl/872091.
@article{osti_872091,
title = {Urea biosensor for hemodialysis monitoring},
author = {Glass, Robert S},
abstractNote = {An electrochemical sensor capable of detecting and quantifying urea in fluids resulting from hemodialysis procedures. The sensor is based upon measurement of the pH change produced in an aqueous environment by the products of the enzyme-catalyzed hydrolysis of urea. The sensor may be fabricated using methods amenable to mass fabrication, resulting in low-cost sensors and thus providing the potential for disposable use. In a typical application, the sensor could be used in treatment centers, in conjunction with an appropriate electronics/computer system, in order to determine the hemodialysis endpoint. The sensor can also be utilized to allow at-home testing to determine if dialysis was necessary. Such a home monitor is similar, in principle, to devices used for blood glucose testing by diabetics, and would require a blood droplet sample by using a finger prick.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

Patent:

Save / Share:

Works referenced in this record:

A miniature palladium-palladium-oxide enzyme electrode for urea determination
journal, June 1984


Metal-metal oxide enzyme electrodes for the determination of urea
journal, January 1990


Urea sensors based on glass pH electrodes with physically immobilized urease
journal, February 1992


New enzyme membrane for enzyme electrodes
journal, May 1986


Assay of Urea by Immobilized Urease Coupled to a Differential pH-Meter
journal, November 1992


Urea sensor based on iridium dioxide electrodes with immobilized urease
journal, January 1983


Metal-Metal Oxide and Metal Oxide Electrodes as pH Sensors
journal, August 1989


Tungsten electrode for urea
journal, January 1990