skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same

Abstract

A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises at least one functionalized hydroxyalkyl phosphine donor group and one or more sulfur or nitrogen donor and a metal combined with the ligand.

Inventors:
 [1];  [1];  [1];  [1];  [1];  [1]
  1. Columbia, MO
Issue Date:
Research Org.:
Univ. of Missouri, Columbia, MO (United States)
OSTI Identifier:
872073
Patent Number(s):
5855867
Assignee:
Curators of University of Missouri (Columbia, MO)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
FG02-89ER60875
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
hydroxymethyl; phosphine; compounds; diagnostic; therapeutic; pharmaceuticals; method; compound; pharmaceutical; comprises; functionalized; hydroxyalkyl; donor; sulfur; nitrogen; metal; combined; ligand; therapeutic pharmaceutical; hydroxyalkyl phosphine; metal combined; phosphine donor; phosphine compounds; pharmaceutical comprises; therapeutic pharmaceuticals; functionalized hydroxyalkyl; hydroxymethyl phosphine; /424/999/

Citation Formats

Katti, Kattesh V, Karra, Srinivasa Rao, Berning, Douglas E, Smith, C Jeffrey, Volkert, Wynn A, and Ketring, Alan R. Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same. United States: N. p., 1999. Web.
Katti, Kattesh V, Karra, Srinivasa Rao, Berning, Douglas E, Smith, C Jeffrey, Volkert, Wynn A, & Ketring, Alan R. Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same. United States.
Katti, Kattesh V, Karra, Srinivasa Rao, Berning, Douglas E, Smith, C Jeffrey, Volkert, Wynn A, and Ketring, Alan R. Fri . "Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same". United States. https://www.osti.gov/servlets/purl/872073.
@article{osti_872073,
title = {Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same},
author = {Katti, Kattesh V and Karra, Srinivasa Rao and Berning, Douglas E and Smith, C Jeffrey and Volkert, Wynn A and Ketring, Alan R},
abstractNote = {A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises at least one functionalized hydroxyalkyl phosphine donor group and one or more sulfur or nitrogen donor and a metal combined with the ligand.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

Patent:

Save / Share:

Works referenced in this record:

Synthesis and crystal and molecular structure of a technetium-hydralazino complex, [TcCl2(C8H5N4)(PPh3)2]·0.75C7H8
journal, July 1990


Stereochemical Control of Transition Metal Complexes by Polyphosphine Ligands
journal, July 1994


Coordination chemistry of phosphorus(III) and phosphorus(V) hydrazides
journal, January 1995


In vitro and in vivo characterization of a 99mTc complex with tris(hydroxymethyl)phosphine (THP)
journal, July 1996


Kinetics and mechanism of reactions of S-protected dithiol monoaminemonoamide (MAMA) ligands with technetium: Characterization of a technetium—thiolate—thioether—MAMA complex, a kinetic intermediate of the reaction
journal, November 1992

  • Rao, T. N.; Gustavson, Linda M.; Srinivasan, Ananthachari
  • International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 19, Issue 8
  • https://doi.org/10.1016/0883-2897(92)90175-X

An empirical correction for absorption anisotropy
journal, January 1995


Chemical and physical properties of radionuclides
journal, January 1987


Water soluble, zero-valent, platinum–, palladium–, and nickel–P(CH 2 OH) 3 complexes:catalysts for the addition of PH 3 to CH 2 O
journal, January 1989


Phase annealing in SHELX-90: direct methods for larger structures
journal, June 1990


Medical Diagnostic Imaging with Complexes of 99mTc
journal, May 1987


Water-soluble tris(hydroxymethyl)phosphine complexes with nickel, palladium, and platinum. Crystal structure of [Pd{P(CH2OH)3}4].cntdot.CH3
journal, July 1992


Hydroxymethyl bis(phosphines) and their palladium(II) and platinum(II) complexes formed via biphasic reactions. Crystal structure of [Pd{(HOH2C)2PC6H4P(CH2OH)2}2]Cl2
journal, January 1996


Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery.
journal, April 1993


The Preparation and Properties of [Re(amine) 4 O 2 ] + Type Ions
journal, June 1965


Co-ordination of (o-aminophenyl)diphenylphosphine in complexes containing the [Mv= O]3+(M = Tc or Re) core
journal, January 1993


Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent.
journal, June 1988


Antibody radiolabeling, problems and promises
journal, January 1990


Coordination compounds in nuclear medicine
journal, May 1993


Aspects of the Chemistry of Technetium Phosphine Complexes
journal, January 1993


Synthesis and characterization of dioxorhenium complexes derived from water-soluble diphosphine tetraphosphonates
journal, January 1996


Synthesis of a new class of Tc chelating agents: N2S2 monoaminemonoamide (mama) ligands
journal, September 1991


Recent Developments in Peptide Drug Delivery to the Brain
journal, July 1992


Tumour targeting with radiolabelled macrocycle–antibody conjugates
journal, January 1990


Chelate radiochemistry: Cleavable linkers lead to altered levels of radioactivity in the liver
journal, January 1988