Process and apparatus for the production of BI-213 cations

Horwitz, E Philip; Hines, John J; Chiarizia, Renato; Dietz, Mark

Title: Process and apparatus for the production of BI-213 cations

Abstract

A process for producing substantially impurity-free Bi-213 cations is disclosed. An aqueous acid feed solution containing Ac-225 cations is contacted with an ion exchange medium to bind the Ac-225 cations and form an Ac-225-laden ion exchange medium. The bound Ac-225 incubates on the ion exchange medium to form Bi-213 cations by radioactive decay. The Bi-213 cations are then recovered from the Ac-225-laden ion exchange medium to form a substantially impurity-free aqueous Bi-213 cation acid solution. An apparatus for carrying out this process is also disclosed.

Inventors:

Horwitz, E Philip ^[1]; Hines, John J ^[2]; Chiarizia, Renato ^[3]; Dietz, Mark ^[3]

Naperville, IL
Newark, IL
Elmhurst, IL

Issue Date:: 1998-01-01

Research Org.:: Argonne National Laboratory (ANL), Argonne, IL (United States)

OSTI Identifier:: 872068

Patent Number(s):: 5854968

Assignee:: Arch Development Corporation (Chicago, IL)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

G - PHYSICS G21 - NUCLEAR PHYSICS G21F - PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K51/1282 - {Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents}

G - PHYSICS G21 - NUCLEAR PHYSICS G21F - PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT
G21F9/007 - {Recovery of isotopes from radioactive waste, e.g. fission products
G21F9/12 - by absorption

G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G4/08 - specially adapted for medical application

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DOE Contract Number:: W-31109-ENG-38

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: process; apparatus; production; bi-213; cations; producing; substantially; impurity-free; disclosed; aqueous; acid; feed; solution; containing; ac-225; contacted; exchange; medium; bind; form; ac-225-laden; bound; incubates; radioactive; decay; recovered; cation; carrying; aqueous acid; feed solution; acid solution; solution containing; radioactive decay; exchange medium; producing substantially; bi-213 cations; cation acid; /423/210/250/

Citation Formats


                    Horwitz, E Philip, Hines, John J, Chiarizia, Renato, and Dietz, Mark. Process and apparatus for the production of BI-213 cations.  United States: N. p., 1998. 
        Web.

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                    Horwitz, E Philip, Hines, John J, Chiarizia, Renato, & Dietz, Mark. Process and apparatus for the production of BI-213 cations.  United States.

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                    Horwitz, E Philip, Hines, John J, Chiarizia, Renato, and Dietz, Mark. Thu .  
        "Process and apparatus for the production of BI-213 cations".  United States.  https://www.osti.gov/servlets/purl/872068.

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@article{osti_872068,

  title        = {Process and apparatus for the production of BI-213 cations},

  author       = {Horwitz, E Philip and Hines, John J and Chiarizia, Renato and Dietz, Mark},

  abstractNote = {A process for producing substantially impurity-free Bi-213 cations is disclosed. An aqueous acid feed solution containing Ac-225 cations is contacted with an ion exchange medium to bind the Ac-225 cations and form an Ac-225-laden ion exchange medium. The bound Ac-225 incubates on the ion exchange medium to form Bi-213 cations by radioactive decay. The Bi-213 cations are then recovered from the Ac-225-laden ion exchange medium to form a substantially impurity-free aqueous Bi-213 cation acid solution. An apparatus for carrying out this process is also disclosed.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1998},

  month        = {1}

}

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Works referenced in this record:

Adjuvant Therapy in Stage I and Stage II Epithelial Ovarian Cancer: Results of Two Prospective Randomized Trials
journal, April 1990

Young, Robert C.; Walton, Leslie A.; Ellenberg, Susan S.
New England Journal of Medicine, Vol. 322, Issue 15
https://doi.org/10.1056/NEJM199004123221501

Separation and preconcentration of actinides by extraction chromatography using a supported liquid anion exchanger: application to the characterization of high-level nuclear waste solutions
journal, June 1995

Horwitz, E. Philip; Dietz, Mark L.; Chiarizia, Renato
Analytica Chimica Acta, Vol. 310, Issue 1
https://doi.org/10.1016/0003-2670(95)00144-O

Synthesis and use as a catalyst support of porous polystyrene with bis(phosphonic acid)-functionalized surfaces
journal, March 1993

Sundell, Mats J.; Pajunen, Esko O.; Hormi, Osmo E. O.
Chemistry of Materials, Vol. 5, Issue 3
https://doi.org/10.1021/cm00027a022

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Title: Process and apparatus for the production of BI-213 cations

Abstract

Citation Formats

Adjuvant Therapy in Stage I and Stage II Epithelial Ovarian Cancer: Results of Two Prospective Randomized Trials journal, April 1990

Separation and preconcentration of actinides by extraction chromatography using a supported liquid anion exchanger: application to the characterization of high-level nuclear waste solutions journal, June 1995

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journal, April 1990

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journal, June 1995

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journal, March 1993