Restoration of normal phenotype in cancer cells

Title: Restoration of normal phenotype in cancer cells

Abstract

A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.

Inventors:

Bissell, Mina J ^[1]; Weaver, Valerie M ^[2]

Berkeley, CA
Oakland, CA

Issue Date:: 1998-01-01

Research Org.:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

OSTI Identifier:: 872022

Patent Number(s):: 5846536

Assignee:: Regents of University of California (Oakland, CA)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K2317/55 - Fab or Fab'

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N5/0693 - {Tumour cells
C12N2500/25 - Insulin-transferrin
C12N2501/392 - Sexual steroids
C12N2501/585 - Integrins
C12N2501/39 - Steroid hormones

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K16/2842 - {against integrin beta1-subunit-containing molecules, e.g. CD29, CD49}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2039/505 - {comprising antibodies}
A61K38/00 - Medicinal preparations containing peptides

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N2506/30 - from cancer cells, e.g. reversion of tumour cells
C12N2501/315 - Prolactin
C12N2501/11 - Epidermal growth factor [EGF]
C12N2500/90 - Serum-free medium, which may still contain naturally-sourced components

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DOE Contract Number:: AC03-76SF00098

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: restoration; normal; phenotype; cancer; cells; method; reversing; expression; malignant; described; comprises; applying; beta; integrin; function-blocking; antibody; assess; progress; therapy; human; breast; epithelial; shown; particularly; responsive; method comprises; cancer therapy; comprises applying; method comprise; epithelial cells; cancer cells; reversing expression; normal phenotype; function-blocking antibody; integrin function-blocking; malignant phenotype; /424/530/

Citation Formats


                    Bissell, Mina J, and Weaver, Valerie M. Restoration of normal phenotype in cancer cells.  United States: N. p., 1998. 
        Web.

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                    Bissell, Mina J, & Weaver, Valerie M. Restoration of normal phenotype in cancer cells.  United States.

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                    Bissell, Mina J, and Weaver, Valerie M. Thu .  
        "Restoration of normal phenotype in cancer cells".  United States.  https://www.osti.gov/servlets/purl/872022.

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@article{osti_872022,

  title        = {Restoration of normal phenotype in cancer cells},

  author       = {Bissell, Mina J and Weaver, Valerie M},

  abstractNote = {A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1998},

  month        = {1}

}

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Works referenced in this record:

Inhibition of Cell Attachment, Invasion and Metastasis of Human Carcinoma Cells by Anti-integrin β ₁ Subunit Antibody
journal, December 1992

Fujita, Shin; Suzuki, Hiroko; Kinoshita, Masao
Japanese Journal of Cancer Research, Vol. 83, Issue 12
https://doi.org/10.1111/j.1349-7006.1992.tb02764.x

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity
journal, December 1991

Streuli, C. H.
The Journal of Cell Biology, Vol. 115, Issue 5
https://doi.org/10.1083/jcb.115.5.1383

Comparative evaluation of integrin ?- and ?-chain expression in colorectal carcinoma cell lines and in their tumours of origin
journal, October 1994

Koretz, K.; Br�derlein, S.; Henne, C.
Virchows Archiv, Vol. 425, Issue 3
https://doi.org/10.1007/BF00196144

Development of anin vitro extracellular matrix assay for studies of brain tumor cell invasion
journal, January 1994

Amar, Arun P.; DeArmond, Stephen J.; Spencer, Donna R.
Journal of Neuro-Oncology, Vol. 20, Issue 1
https://doi.org/10.1007/BF01057956

Another Anniversary for the War on Cancer
journal, March 1994

Dermer, Gerald B.
Bio/Technology, Vol. 12, Issue 3
https://doi.org/10.1038/nbt0394-320

Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumour cells
journal, October 1992

Pignatelli, M.; Liu, D.; Nasim, Mm
British Journal of Cancer, Vol. 66, Issue 4
https://doi.org/10.1038/bjc.1992.328

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Title: Restoration of normal phenotype in cancer cells

Abstract

Citation Formats

Inhibition of Cell Attachment, Invasion and Metastasis of Human Carcinoma Cells by Anti-integrin β 1 Subunit Antibody journal, December 1992

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity journal, December 1991

Comparative evaluation of integrin ?- and ?-chain expression in colorectal carcinoma cell lines and in their tumours of origin journal, October 1994

Development of anin vitro extracellular matrix assay for studies of brain tumor cell invasion journal, January 1994

Another Anniversary for the War on Cancer journal, March 1994

Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumour cells journal, October 1992

Inhibition of Cell Attachment, Invasion and Metastasis of Human Carcinoma Cells by Anti-integrin β ₁ Subunit Antibody
journal, December 1992

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity
journal, December 1991

Comparative evaluation of integrin ?- and ?-chain expression in colorectal carcinoma cell lines and in their tumours of origin
journal, October 1994

Development of anin vitro extracellular matrix assay for studies of brain tumor cell invasion
journal, January 1994

Another Anniversary for the War on Cancer
journal, March 1994

Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumour cells
journal, October 1992