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Title: Restoration of normal phenotype in cancer cells

Abstract

A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.

Inventors:
 [1];  [2]
  1. (Berkeley, CA)
  2. (Oakland, CA)
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
OSTI Identifier:
872022
Patent Number(s):
5846536
Assignee:
Regents of University of California (Oakland, CA) LBNL
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
restoration; normal; phenotype; cancer; cells; method; reversing; expression; malignant; described; comprises; applying; beta; integrin; function-blocking; antibody; assess; progress; therapy; human; breast; epithelial; shown; particularly; responsive; method comprises; cancer therapy; comprises applying; method comprise; epithelial cells; cancer cells; reversing expression; normal phenotype; function-blocking antibody; integrin function-blocking; malignant phenotype; /424/530/

Citation Formats

Bissell, Mina J., and Weaver, Valerie M. Restoration of normal phenotype in cancer cells. United States: N. p., 1998. Web.
Bissell, Mina J., & Weaver, Valerie M. Restoration of normal phenotype in cancer cells. United States.
Bissell, Mina J., and Weaver, Valerie M. Thu . "Restoration of normal phenotype in cancer cells". United States. https://www.osti.gov/servlets/purl/872022.
@article{osti_872022,
title = {Restoration of normal phenotype in cancer cells},
author = {Bissell, Mina J. and Weaver, Valerie M.},
abstractNote = {A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {1}
}

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