Restoration of normal phenotype in cancer cells
Abstract
A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.
- Inventors:
-
- Berkeley, CA
- Oakland, CA
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- OSTI Identifier:
- 872022
- Patent Number(s):
- 5846536
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC03-76SF00098
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- restoration; normal; phenotype; cancer; cells; method; reversing; expression; malignant; described; comprises; applying; beta; integrin; function-blocking; antibody; assess; progress; therapy; human; breast; epithelial; shown; particularly; responsive; method comprises; cancer therapy; comprises applying; method comprise; epithelial cells; cancer cells; reversing expression; normal phenotype; function-blocking antibody; integrin function-blocking; malignant phenotype; /424/530/
Citation Formats
Bissell, Mina J, and Weaver, Valerie M. Restoration of normal phenotype in cancer cells. United States: N. p., 1998.
Web.
Bissell, Mina J, & Weaver, Valerie M. Restoration of normal phenotype in cancer cells. United States.
Bissell, Mina J, and Weaver, Valerie M. Thu .
"Restoration of normal phenotype in cancer cells". United States. https://www.osti.gov/servlets/purl/872022.
@article{osti_872022,
title = {Restoration of normal phenotype in cancer cells},
author = {Bissell, Mina J and Weaver, Valerie M},
abstractNote = {A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {1}
}
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