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Title: Restoration of normal phenotype in cancer cells

Abstract

A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.

Inventors:
 [1];  [2]
  1. Berkeley, CA
  2. Oakland, CA
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
872022
Patent Number(s):
5846536
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
restoration; normal; phenotype; cancer; cells; method; reversing; expression; malignant; described; comprises; applying; beta; integrin; function-blocking; antibody; assess; progress; therapy; human; breast; epithelial; shown; particularly; responsive; method comprises; cancer therapy; comprises applying; method comprise; epithelial cells; cancer cells; reversing expression; normal phenotype; function-blocking antibody; integrin function-blocking; malignant phenotype; /424/530/

Citation Formats

Bissell, Mina J, and Weaver, Valerie M. Restoration of normal phenotype in cancer cells. United States: N. p., 1998. Web.
Bissell, Mina J, & Weaver, Valerie M. Restoration of normal phenotype in cancer cells. United States.
Bissell, Mina J, and Weaver, Valerie M. Thu . "Restoration of normal phenotype in cancer cells". United States. https://www.osti.gov/servlets/purl/872022.
@article{osti_872022,
title = {Restoration of normal phenotype in cancer cells},
author = {Bissell, Mina J and Weaver, Valerie M},
abstractNote = {A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {1}
}

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Works referenced in this record:

Inhibition of Cell Attachment, Invasion and Metastasis of Human Carcinoma Cells by Anti-integrin β 1 Subunit Antibody
journal, December 1992


Development of anin vitro extracellular matrix assay for studies of brain tumor cell invasion
journal, January 1994


Another Anniversary for the War on Cancer
journal, March 1994


Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumour cells
journal, October 1992