Isolation and characterization of Agouti: a diabetes/obesity related gene
Abstract
The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.
- Inventors:
-
- Knoxville, TN
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- OSTI Identifier:
- 872007
- Patent Number(s):
- 5843652
- Assignee:
- Lockheed Martin Energy Systems, Inc. (Oak Ridge, TN)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- isolation; characterization; agouti; diabetes; obesity; related; relates; cloning; expression; analogous; genes; transformed; transfected; transgenic; mice; provides; animal; model; study; tumors; testing; potential; therapeutic; agents; oligonucleotide; probes; detection; mutations; recombinant; production; product; antibodies; diagnostic; oligonucleotide probes; therapeutic agents; recombinant production; provides oligonucleotide; transgenic mice; therapeutic agent; animal model; analogous genes; potential therapeutic; obesity related; oligonucleotide probe; /435/999/
Citation Formats
Woychik, Richard P. Isolation and characterization of Agouti: a diabetes/obesity related gene. United States: N. p., 1998.
Web.
Woychik, Richard P. Isolation and characterization of Agouti: a diabetes/obesity related gene. United States.
Woychik, Richard P. Thu .
"Isolation and characterization of Agouti: a diabetes/obesity related gene". United States. https://www.osti.gov/servlets/purl/872007.
@article{osti_872007,
title = {Isolation and characterization of Agouti: a diabetes/obesity related gene},
author = {Woychik, Richard P},
abstractNote = {The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {1}
}
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Works referenced in this record:
Molecular structure and chromosomal mapping of the human homolog of the agouti gene.
journal, October 1994
- Kwon, H. Y.; Bultman, S. J.; Loffler, C.
- Proceedings of the National Academy of Sciences, Vol. 91, Issue 21
Detection of human apolipoprotein E3, E2, and E4 genotypes by an allele-specific oligonucleotide-primed polymerase chain reaction assay: development and validation
journal, July 1991
- Green, E. K.; Bain, S. C.; Day, P. J.
- Clinical Chemistry, Vol. 37, Issue 7