Isolation and characterization of Agouti: a diabetes/obesity related gene

Title: Isolation and characterization of Agouti: a diabetes/obesity related gene

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Abstract

The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.

Inventors:

Woychik, Richard P ^[1]

Knoxville, TN

Issue Date:: 1998-01-01

Research Org.:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

OSTI Identifier:: 872007

Patent Number(s):: 5843652

Assignee:: Lockheed Martin Energy Systems, Inc. (Oak Ridge, TN)

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: isolation; characterization; agouti; diabetes; obesity; related; relates; cloning; expression; analogous; genes; transformed; transfected; transgenic; mice; provides; animal; model; study; tumors; testing; potential; therapeutic; agents; oligonucleotide; probes; detection; mutations; recombinant; production; product; antibodies; diagnostic; oligonucleotide probes; therapeutic agents; recombinant production; provides oligonucleotide; transgenic mice; therapeutic agent; animal model; analogous genes; potential therapeutic; obesity related; oligonucleotide probe; /435/999/

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                    Woychik, Richard P. Isolation and characterization of Agouti: a diabetes/obesity related gene.  United States: N. p., 1998. 
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                    Woychik, Richard P. Isolation and characterization of Agouti: a diabetes/obesity related gene.  United States.

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                    Woychik, Richard P. Thu .  
        "Isolation and characterization of Agouti: a diabetes/obesity related gene".  United States.  https://www.osti.gov/servlets/purl/872007.

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@article{osti_872007,

  title        = {Isolation and characterization of Agouti: a diabetes/obesity related gene},

  author       = {Woychik, Richard P},

  abstractNote = {The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1998},

  month        = {1}

}

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