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Title: Arrays of nucleic acid probes on biological chips

Abstract

DNA chips containing arrays of oligonucleotide probes can be used to determine whether a target nucleic acid has a nucleotide sequence identical to or different from a specific reference sequence. The array of probes comprises probes exactly complementary to the reference sequence, as well as probes that differ by one or more bases from the exactly complementary probes.

Inventors:
 [1];  [2];  [1];  [3];  [3];  [1];  [1];  [4];  [5]
  1. Palo Alto, CA
  2. Los Altos, CA
  3. Mt. View, CA
  4. San Jose, CA
  5. Menlo Park, CA
Issue Date:
Research Org.:
Affymetrix, Inc. (Santa Clara, CA)
OSTI Identifier:
871979
Patent Number(s):
5837832
Application Number:
08/441,887
Assignee:
Affymetrix, Inc. (Santa Clara, CA)
DOE Contract Number:  
FG03-92ER81275; 1R01HG00813-01
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
arrays; nucleic; acid; probes; biological; chips; dna; containing; oligonucleotide; determine; target; nucleotide; sequence; identical; specific; reference; array; comprises; exactly; complementary; bases; oligonucleotide probes; reference sequence; acid probes; nucleotide sequence; nucleic acid; target nucleic; acid probe; oligonucleotide probe; target nuclei; biological chips; /999/422/435/436/

Citation Formats

Chee, Mark, Cronin, Maureen T, Fodor, Stephen P. A., Huang, Xiaohua X, Hubbell, Earl A, Lipshutz, Robert J, Lobban, Peter E, Morris, MacDonald S, and Sheldon, Edward L. Arrays of nucleic acid probes on biological chips. United States: N. p., 1998. Web.
Chee, Mark, Cronin, Maureen T, Fodor, Stephen P. A., Huang, Xiaohua X, Hubbell, Earl A, Lipshutz, Robert J, Lobban, Peter E, Morris, MacDonald S, & Sheldon, Edward L. Arrays of nucleic acid probes on biological chips. United States.
Chee, Mark, Cronin, Maureen T, Fodor, Stephen P. A., Huang, Xiaohua X, Hubbell, Earl A, Lipshutz, Robert J, Lobban, Peter E, Morris, MacDonald S, and Sheldon, Edward L. Tue . "Arrays of nucleic acid probes on biological chips". United States. https://www.osti.gov/servlets/purl/871979.
@article{osti_871979,
title = {Arrays of nucleic acid probes on biological chips},
author = {Chee, Mark and Cronin, Maureen T and Fodor, Stephen P. A. and Huang, Xiaohua X and Hubbell, Earl A and Lipshutz, Robert J and Lobban, Peter E and Morris, MacDonald S and Sheldon, Edward L},
abstractNote = {DNA chips containing arrays of oligonucleotide probes can be used to determine whether a target nucleic acid has a nucleotide sequence identical to or different from a specific reference sequence. The array of probes comprises probes exactly complementary to the reference sequence, as well as probes that differ by one or more bases from the exactly complementary probes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {11}
}

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