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Title: Diagnostic method employing MSH2 protein

Abstract

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

Inventors:
 [1];  [2];  [2]
  1. (Bergmansgatan, FI)
  2. (Baltimore, MD)
Issue Date:
Research Org.:
ELEANOR ROOSEVELT INSTITUTE
OSTI Identifier:
871976
Patent Number(s):
5837443
Assignee:
Johns Hopkins University (Baltimore, MD) CHO
DOE Contract Number:  
FG02-91ER61139
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
diagnostic; method; employing; msh2; protein; human; responsible; hereditary; non-polyposis; colorectal; cancer; identified; virtue; homology; muts; genes; involved; dna; mismatch; repair; sequence; cdna; clones; provided; demonstrate; existence; germ; line; mutations; hnpcc; kindreds; replication; error; rer; tumor; cells; non-polyposis colorectal; colorectal cancer; cdna clones; cdna clone; diagnostic method; hereditary non-polyposis; tumor cells; replication error; mismatch repair; method employing; human msh2; germ line; msh2 protein; dna mismatch; line mutations; employing msh2; method employ; /435/530/

Citation Formats

de la Chapelle, Albert, Vogelstein, Bert, and Kinzler, Kenneth W. Diagnostic method employing MSH2 protein. United States: N. p., 1998. Web.
de la Chapelle, Albert, Vogelstein, Bert, & Kinzler, Kenneth W. Diagnostic method employing MSH2 protein. United States.
de la Chapelle, Albert, Vogelstein, Bert, and Kinzler, Kenneth W. Thu . "Diagnostic method employing MSH2 protein". United States. https://www.osti.gov/servlets/purl/871976.
@article{osti_871976,
title = {Diagnostic method employing MSH2 protein},
author = {de la Chapelle, Albert and Vogelstein, Bert and Kinzler, Kenneth W.},
abstractNote = {The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {1}
}

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