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Title: Method for improved selectivity in photo-activation and detection of molecular diagnostic agents

Abstract

A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.

Inventors:
 [1];  [2];  [2]
  1. (Oak Ridge, TN)
  2. (Knoxville, TN)
Issue Date:
Research Org.:
LOCKHEED MARTIN ENRGY SYST INC
OSTI Identifier:
871959
Patent Number(s):
5832931
Assignee:
Photogen, Inc. (Oak Ridge, TN) ORNL
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; improved; selectivity; photo-activation; detection; molecular; diagnostic; agents; imaging; particular; volume; plant; animal; tissue; contains; photo-active; agent; steps; treating; light; sufficient; promote; simultaneous; two-photon; excitation; contained; photo-activating; producing; photo-activated; emits; energy; detecting; emitted; detected; signal; characteristic; material; two-photon excitation; photo-activated molecular; simultaneous two-photon; photo-active molecular; molecular agent; animal tissue; particular volume; improved selectivity; energy emitted; light sufficient; material contains; diagnostic agent; diagnostic agents; /128/600/

Citation Formats

Wachter, Eric A., Fisher, Walter G., and Dees, H. Craig. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents. United States: N. p., 1998. Web.
Wachter, Eric A., Fisher, Walter G., & Dees, H. Craig. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents. United States.
Wachter, Eric A., Fisher, Walter G., and Dees, H. Craig. Thu . "Method for improved selectivity in photo-activation and detection of molecular diagnostic agents". United States. https://www.osti.gov/servlets/purl/871959.
@article{osti_871959,
title = {Method for improved selectivity in photo-activation and detection of molecular diagnostic agents},
author = {Wachter, Eric A. and Fisher, Walter G. and Dees, H. Craig},
abstractNote = {A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method includes the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the at least one photo-active molecular agent in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention is also a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {1}
}

Patent:

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