Title: Method for improved selectivity in photo-activation of molecular agents

Abstract

A method for the treatment of a particular volume of plant or animal tissue comprising the steps of treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue. There is also disclosed a method for the treatment of cancer in plant or animal tissue and a method for producing at least one photo-activated molecular agent in a particular volume of a material.

Inventors:

Fisher, Walter G ^[1]; Wachter, Eric A ^[2]; Dees, H Craig ^[1]

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+ Show Inventor Affiliations

1. Knoxville, TN
2. Oak Ridge, TN

Issue Date:

1998-01-01

Research Org.:

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

OSTI Identifier:

871945

Patent Number(s):

5829448

Assignee:

Photogen, Inc. (Knoxville, TN)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A61B2017/00057 - {Light}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P35/00 - Antineoplastic agents

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K41/008 - {Two-Photon or Multi-Photon PDT, e.g. with upconverting dyes or photosensitisers}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY

A61N5/062 - {Photodynamic therapy, i.e. excitation of an agent}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K41/0057 - {Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

B82Y15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

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DOE Contract Number:  

AC05-84OR21400

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

method; improved; selectivity; photo-activation; molecular; agents; treatment; particular; volume; plant; animal; tissue; comprising; steps; treating; photo-active; agent; retains; portion; light; sufficient; promote; simultaneous; two-photon; excitation; retained; active; disclosed; cancer; producing; photo-activated; material; two-photon excitation; photo-activated molecular; simultaneous two-photon; photo-active molecular; molecular agent; animal tissue; particular volume; improved selectivity; molecular agents; tissue retains; tissue comprising; agent retained; light sufficient; /128/604/