Title: Cell-targeted lytic pore-forming agents

Abstract

A chimeric compound that contains a cell-specific ligand linked to a pore-forming agent capable of lysing a cell.

Inventors:

Bayley, Hagen ^[1]; Walker, Barbara J ^[2]

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+ Show Inventor Affiliations

1. Grafton, MA
2. Auburn, MA

Issue Date:

1998-01-01

Research Org.:

Worcester Foundation

OSTI Identifier:

871917

Patent Number(s):

5824776

Assignee:

Worcester Foundation for Experimental Biology (Shrewsbury, MA)

Patent Classifications (CPCs):

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/5014 - {for testing toxicity}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P37/00 - Drugs for immunological or allergic disorders

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K2319/00 - Fusion polypeptide
C07K2319/50 - containing protease site
C07K16/18 - against material from animals or humans

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S530/825 - Bacteria

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P35/00 - Antineoplastic agents

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K38/00 - Medicinal preparations containing peptides

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/5008 - {for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics}

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N15/62 - DNA sequences coding for fusion proteins

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation {

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K14/31 - from Staphylococcus

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K47/585 - {Ion exchange resins, e.g. polystyrene sulfonic acid resin}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K2319/55 - containing a fusion with a toxin, e.g. diphteria toxin

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/5011 - {for testing antineoplastic activity}

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DOE Contract Number:  

FG02-90ER20018

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

cell-targeted; lytic; pore-forming; agents; chimeric; compound; contains; cell-specific; ligand; linked; agent; capable; lysing; cell; agent capable; pore-forming agents; pore-forming agent; chimeric compound; cell-specific ligand; ligand linked; forming agent; cell-targeted lytic; lytic pore-forming; /530/