Optical reaction cell and light source for ›18F! fluoride radiotracer synthesis
Abstract
Apparatus for performing organic synthetic reactions, particularly no-carrier-added nucleophilic radiofluorination reactions for PET radiotracer production. The apparatus includes an optical reaction cell and a source of broadband infrared radiant energy, which permits direct coupling of the emitted radiant energy with the reaction medium to heat the reaction medium. Preferably, the apparatus includes means for focusing the emitted radiant energy into the reaction cell, and the reaction cell itself is preferably configured to reflect transmitted radiant energy back into the reaction medium to further improve the efficiency of the apparatus. The apparatus is well suited to the production of high-yield syntheses of 2-›.sup.18 F!fluoro-2-deoxy-D-glucose. Also provided is a method for performing organic synthetic reactions, including the manufacture of ›.sup.18 F!-labeled compounds useful as PET radiotracers, and particularly for the preparation of 2-›.sup.18 F!fluoro-2-deoxy-D-glucose in higher yields than previously possible.
- Inventors:
-
- Patchogue, NY
- Bellport, NY
- Islip, NY
- Issue Date:
- Research Org.:
- Associated Universities, Inc., Upton, NY (United States)
- OSTI Identifier:
- 871843
- Patent Number(s):
- 5808020
- Application Number:
- 08/694,398
- Assignee:
- Associated Universities, Inc. (Washington, DC)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- optical; reaction; cell; light; source; 18f; fluoride; radiotracer; synthesis; apparatus; performing; organic; synthetic; reactions; particularly; no-carrier-added; nucleophilic; radiofluorination; pet; production; broadband; infrared; radiant; energy; permits; direct; coupling; emitted; medium; heat; preferably; means; focusing; configured; reflect; transmitted; improve; efficiency; suited; high-yield; syntheses; 2-; 18; fluoro-2-deoxy-d-glucose; provided; method; including; manufacture; -labeled; compounds; useful; radiotracers; preparation; yields; previously; compounds useful; reaction medium; synthesis apparatus; radiant energy; light source; reaction cell; labeled compounds; permits direct; radiotracer synthesis; direct coupling; /999/204/422/
Citation Formats
Ferrieri, Richard A, Schlyer, David, and Becker, Richard J. Optical reaction cell and light source for ›18F! fluoride radiotracer synthesis. United States: N. p., 1998.
Web.
Ferrieri, Richard A, Schlyer, David, & Becker, Richard J. Optical reaction cell and light source for ›18F! fluoride radiotracer synthesis. United States.
Ferrieri, Richard A, Schlyer, David, and Becker, Richard J. Tue .
"Optical reaction cell and light source for ›18F! fluoride radiotracer synthesis". United States. https://www.osti.gov/servlets/purl/871843.
@article{osti_871843,
title = {Optical reaction cell and light source for ›18F! fluoride radiotracer synthesis},
author = {Ferrieri, Richard A and Schlyer, David and Becker, Richard J},
abstractNote = {Apparatus for performing organic synthetic reactions, particularly no-carrier-added nucleophilic radiofluorination reactions for PET radiotracer production. The apparatus includes an optical reaction cell and a source of broadband infrared radiant energy, which permits direct coupling of the emitted radiant energy with the reaction medium to heat the reaction medium. Preferably, the apparatus includes means for focusing the emitted radiant energy into the reaction cell, and the reaction cell itself is preferably configured to reflect transmitted radiant energy back into the reaction medium to further improve the efficiency of the apparatus. The apparatus is well suited to the production of high-yield syntheses of 2-›.sup.18 F!fluoro-2-deoxy-D-glucose. Also provided is a method for performing organic synthetic reactions, including the manufacture of ›.sup.18 F!-labeled compounds useful as PET radiotracers, and particularly for the preparation of 2-›.sup.18 F!fluoro-2-deoxy-D-glucose in higher yields than previously possible.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {9}
}
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