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Title: Optical reaction cell and light source for ›18F! fluoride radiotracer synthesis

Abstract

Apparatus for performing organic synthetic reactions, particularly no-carrier-added nucleophilic radiofluorination reactions for PET radiotracer production. The apparatus includes an optical reaction cell and a source of broadband infrared radiant energy, which permits direct coupling of the emitted radiant energy with the reaction medium to heat the reaction medium. Preferably, the apparatus includes means for focusing the emitted radiant energy into the reaction cell, and the reaction cell itself is preferably configured to reflect transmitted radiant energy back into the reaction medium to further improve the efficiency of the apparatus. The apparatus is well suited to the production of high-yield syntheses of 2-›.sup.18 F!fluoro-2-deoxy-D-glucose. Also provided is a method for performing organic synthetic reactions, including the manufacture of ›.sup.18 F!-labeled compounds useful as PET radiotracers, and particularly for the preparation of 2-›.sup.18 F!fluoro-2-deoxy-D-glucose in higher yields than previously possible.

Inventors:
 [1];  [2];  [3]
+ Show Inventor Affiliations
  1. Patchogue, NY
  2. Bellport, NY
  3. Islip, NY
Issue Date:
Research Org.:
Associated Universities, Inc., Upton, NY (United States)
OSTI Identifier:
871843
Patent Number(s):
5808020
Application Number:
08/694,398
Assignee:
Associated Universities, Inc. (Washington, DC)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
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DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
optical; reaction; cell; light; source; 18f; fluoride; radiotracer; synthesis; apparatus; performing; organic; synthetic; reactions; particularly; no-carrier-added; nucleophilic; radiofluorination; pet; production; broadband; infrared; radiant; energy; permits; direct; coupling; emitted; medium; heat; preferably; means; focusing; configured; reflect; transmitted; improve; efficiency; suited; high-yield; syntheses; 2-; 18; fluoro-2-deoxy-d-glucose; provided; method; including; manufacture; -labeled; compounds; useful; radiotracers; preparation; yields; previously; compounds useful; reaction medium; synthesis apparatus; radiant energy; light source; reaction cell; labeled compounds; permits direct; radiotracer synthesis; direct coupling; /999/204/422/

Citation Formats

Ferrieri, Richard A, Schlyer, David, and Becker, Richard J. Optical reaction cell and light source for ›18F! fluoride radiotracer synthesis. United States: N. p., 1998. Web.
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Ferrieri, Richard A, Schlyer, David, & Becker, Richard J. Optical reaction cell and light source for ›18F! fluoride radiotracer synthesis. United States.
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Ferrieri, Richard A, Schlyer, David, and Becker, Richard J. Tue . "Optical reaction cell and light source for ›18F! fluoride radiotracer synthesis". United States. https://www.osti.gov/servlets/purl/871843.
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@article{osti_871843,
title = {Optical reaction cell and light source for ›18F! fluoride radiotracer synthesis},
author = {Ferrieri, Richard A and Schlyer, David and Becker, Richard J},
abstractNote = {Apparatus for performing organic synthetic reactions, particularly no-carrier-added nucleophilic radiofluorination reactions for PET radiotracer production. The apparatus includes an optical reaction cell and a source of broadband infrared radiant energy, which permits direct coupling of the emitted radiant energy with the reaction medium to heat the reaction medium. Preferably, the apparatus includes means for focusing the emitted radiant energy into the reaction cell, and the reaction cell itself is preferably configured to reflect transmitted radiant energy back into the reaction medium to further improve the efficiency of the apparatus. The apparatus is well suited to the production of high-yield syntheses of 2-›.sup.18 F!fluoro-2-deoxy-D-glucose. Also provided is a method for performing organic synthetic reactions, including the manufacture of ›.sup.18 F!-labeled compounds useful as PET radiotracers, and particularly for the preparation of 2-›.sup.18 F!fluoro-2-deoxy-D-glucose in higher yields than previously possible.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {9}
}
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Works referenced in this record:

Computer-aided synthesis (CAS) of no-carrier-added 2-[18F]Fluoro-2-deoxy-d-glucose: an efficient automated system for the aminopolyether-supported nucleophilic fluorination
journal, January 1990

Synthesis of 14 (R,S)-[18F]fluoro-6-thia-heptadecanoic acid (FTHA)
journal, September 1991

Electrochemical cell design for in-situ IR study of reactions involving high electric current and gas evolution
journal, June 1989

Preparation of 18F-labeled 6- and 2-fluoro-9-benzylpurine as a potential brain-scanning agent
journal, August 1982

Back-to-back “one-pot” [18F]FDG syntheses in a single Siemens-CTI chemistry process control unit
journal, May 1996

Simple construction of an infrared optically transparent thin-layer electrochemical cell
journal, November 1991

Recommendation for a practical production of [2-18F]fluoro-2-deoxy-D-glucose
journal, January 1987

Reusable thin-layer spectroelectrochemical cell for nonaqueous solvent systems
journal, April 1988

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