GDP-L-fucose: .beta.-D-galactoside 2-.alpha.-L-fucosyltransferases, DNA sequences encoding the same, method for producing the same and a method of genotyping a person

Lowe, John B; Lennon, Gregory; Rouquier, Sylvie; Giorgi, Dominique; Kelly, Robert J

Title: GDP-L-fucose: .beta.-D-galactoside 2-.alpha.-L-fucosyltransferases, DNA sequences encoding the same, method for producing the same and a method of genotyping a person

Abstract

The gene encoding GDP-L-fucose: .beta.-D-Galactoside 2-.alpha.-L-fucosyltransferase has been cloned, and a mutation in this gene has been found to be responsible for an individual being a non-secretor.

Inventors:

Lowe, John B ^[1]; Lennon, Gregory ^[2]; Rouquier, Sylvie ^[3]; Giorgi, Dominique ^[3]; Kelly, Robert J ^[4]

3125 Bolgos Cir., Ann Arbor, MI 48105
8309 Norris Canyon, Castro Valley, CA 94552
5, rue du Cannau, 34000 Montpellier, FR
3164 Concord, Trenton, MI 48183

Issue Date:: 1998-01-01

Research Org.:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

OSTI Identifier:: 871841

Patent Number(s):: 5807732

Assignee:: Lowe, John B. (3125 Bolgos Cir., Ann Arbor, MI 48105);Lennon, Gregory (8309 Norris Canyon, Castro Valley, CA 94552);Rouquier, Sylvie (5, rue du Cannau, 34000 Montpellier, FR);Giorgi, Dominique (5, rue du Cannau, 34000 Montpellier, FR);Kelly, Robert J. (3164 Concord, Trenton, MI 48183)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY
A01K2217/05 - Animals comprising random inserted nucleic acids

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K38/00 - Medicinal preparations containing peptides

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N9/1051 - {Hexosyltransferases

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C12P19/18 - produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins

Show less

DOE Contract Number:: W-7405-ENG-48

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: gdp-l-fucose; beta; -d-galactoside; 2-; alpha; -l-fucosyltransferases; dna; sequences; encoding; method; producing; genotyping; person; -l-fucosyltransferase; cloned; mutation; found; responsible; individual; non-secretor; sequences encoding; dna sequences; dna sequence; /435/999/

Citation Formats


                    Lowe, John B, Lennon, Gregory, Rouquier, Sylvie, Giorgi, Dominique, and Kelly, Robert J. GDP-L-fucose: .beta.-D-galactoside 2-.alpha.-L-fucosyltransferases, DNA sequences encoding the same, method for producing the same and a method of genotyping a person.  United States: N. p., 1998. 
        Web.

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                    Lowe, John B, Lennon, Gregory, Rouquier, Sylvie, Giorgi, Dominique, & Kelly, Robert J. GDP-L-fucose: .beta.-D-galactoside 2-.alpha.-L-fucosyltransferases, DNA sequences encoding the same, method for producing the same and a method of genotyping a person.  United States.

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                    Lowe, John B, Lennon, Gregory, Rouquier, Sylvie, Giorgi, Dominique, and Kelly, Robert J. Thu .  
        "GDP-L-fucose: .beta.-D-galactoside 2-.alpha.-L-fucosyltransferases, DNA sequences encoding the same, method for producing the same and a method of genotyping a person".  United States.  https://www.osti.gov/servlets/purl/871841.

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@article{osti_871841,

  title        = {GDP-L-fucose: .beta.-D-galactoside 2-.alpha.-L-fucosyltransferases, DNA sequences encoding the same, method for producing the same and a method of genotyping a person},

  author       = {Lowe, John B and Lennon, Gregory and Rouquier, Sylvie and Giorgi, Dominique and Kelly, Robert J},

  abstractNote = {The gene encoding GDP-L-fucose: .beta.-D-Galactoside 2-.alpha.-L-fucosyltransferase has been cloned, and a mutation in this gene has been found to be responsible for an individual being a non-secretor.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1998},

  month        = {1}

}

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Title: GDP-L-fucose: .beta.-D-galactoside 2-.alpha.-L-fucosyltransferases, DNA sequences encoding the same, method for producing the same and a method of genotyping a person

Abstract

Citation Formats

Cloning and sequencing of cDNA of bovine N-acetylglucosamine (beta 1-4)galactosyltransferase. journal, July 1986

Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant journal, June 1994

Enzymatic basis for the accumulation of glycolipids with X and dimeric X determinants in human lung cancer cells (NCI-H69). journal, June 1985

Molecular cloning and biological characterization of a human gene, ERCC2, that corrects the nucleotide excision repair defect in CHO UV5 cells. journal, March 1988

Controlled Linkage Techniques for Monosaccharides Introduced: Methods allow automation of oligosaccharide production, offer route, similar to oligopeptide synthesis, to specialized carbohydrates journal, August 1989

Stable transformation of mouse L cells for human membrane T-cell differentiation antigens, HLA and beta 2-microglobulin: selection by fluorescence-activated cell sorting. journal, January 1983

Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant. journal, August 1994

Purification of the beta-N-acetylglucosaminide alpha 1----3-fucosyltransferase from human serum. journal, February 1992

Purification and characterization of a UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase from Ehrlich ascites tumor cells. journal, May 1986

The isolation and sequence of the gene encoding T8: A molecule defining functional classes of T lymphocytes journal, February 1985

The cloning and expression of a human α-1,3 fucosyltransferase capable of forming the E-selectin ligand journal, August 1992

Capitalizing on Carbohydrates journal, February 1990

Co-transformation of Lec1 CHO cells with N-acetylgucosaminyltransferase 1 activity and a selectable marker journal, March 1990

Co-purification of the Lewis blood group N-acetylglucosaminide alpha 1 goes to 4 fucosyltransferase and an N-acetylglucosaminide alpha 1 goes to 3 fucosyltransferase from human milk. journal, October 1981

Protective effects of sialylated oligosaccharides in immune complex-induced acute lung injury. journal, August 1993

Biosynthesis of terminal Gal alpha 1—-3Gal beta 1—-4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1—-3-galactosyltransferase from calf thymus. journal, October 1985

Acceptor specificity and tissue distribution of three human alpha-3-fucosyltransferases journal, July 1990

A Cloned Human DNA Restriction Fragment Determines Expression of a GDP-L-fucose:β-D-Galactoside 2-α-L-fucosytransferase in Transfected Cells journal, July 1989

Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland. journal, June 1980

Bovine galactosyltransferase: identification of a clone by direct immunological screening of a cDNA expression library. journal, March 1986

Molecular Cloning and Expression of Two Types of Rabbit β-Galactoside α1,2-Fucosyltransferase journal, April 1995

Gene transfer, expression, and molecular cloning of the human transferrin receptor gene journal, May 1984

Enzyme-catalyzed synthesis of carbohydrates journal, January 1989

Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland. journal, June 1980

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor journal, July 1978

A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase. journal, August 1990

Gene transfer and molecular cloning of the human NGF receptor journal, April 1986

Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes. journal, December 1992

Stable Expression of Blood Group H Determinants and GDP-L-fucose: β-D-galactoside 2-α-L-Fucosyltransferase in Mouse Cells After Transfection with Human DNA journal, February 1989

A new technique for the assay of infectivity of human adenovirus 5 DNA journal, April 1973

Purification of theN-acetylglucosaminide ?(1?3/4) fucosyltransferase of human milk journal, January 1989

Purification of the secretor-type beta-galactoside alpha 1----2-fucosyltransferase from human serum. journal, February 1992

DNA-mediated transformation of N-acetylglucosaminyltransferase I activity into an enzyme deficient cell line journal, March 1989

Primary structure of beta-galactoside alpha 2,6-sialyltransferase. Conversion of membrane-bound enzyme to soluble forms by cleavage of the NH2-terminal signal anchor. journal, December 1987

Protective effects of oligosaccharides in P-selectin-dependent lung injury journal, July 1993

Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen. journal, September 1990

Isolation of a cDNA encoding a murine UDPgalactose:beta-D-galactosyl- 1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase: expression cloning by gene transfer. journal, November 1989

Purification of a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase and a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase to homogeneity from rat liver. journal, November 1982

Human α-1,3 Fucosyltransferase (FucT-VI) Gene Is Located at Only 13 kb 3′ to the Lewis Type Fucosyltransferase (FucT-III) Gene on Chromosome 19 journal, January 1993

Sequence and Expression of a Candidate for the Human Secretor Blood Group α(1,2)Fucosyltransferase Gene (FUT2) journal, March 1995

Isolation of a cDNA coding for human galactosyltransferase journal, August 1986

Evidence for two distinct α(1,2)-fucosyltransferase genes differentially expressed throughout the rat colon journal, June 1994

Purification and Characterization of Secretory-Type GDP-L-Fucose: β-D-Galactoside 2-α-L-Fucosyltransferase from Human Gastric Mucosa1 journal, September 1995

Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes. journal, May 1994

Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities. journal, February 1992

Cloning and sequencing of cDNA of bovine N-acetylglucosamine (beta 1-4)galactosyltransferase.
journal, July 1986

Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant
journal, June 1994

Enzymatic basis for the accumulation of glycolipids with X and dimeric X determinants in human lung cancer cells (NCI-H69).
journal, June 1985

Molecular cloning and biological characterization of a human gene, ERCC2, that corrects the nucleotide excision repair defect in CHO UV5 cells.
journal, March 1988

Controlled Linkage Techniques for Monosaccharides Introduced: Methods allow automation of oligosaccharide production, offer route, similar to oligopeptide synthesis, to specialized carbohydrates
journal, August 1989

Stable transformation of mouse L cells for human membrane T-cell differentiation antigens, HLA and beta 2-microglobulin: selection by fluorescence-activated cell sorting.
journal, January 1983

Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant.
journal, August 1994

Purification of the beta-N-acetylglucosaminide alpha 1----3-fucosyltransferase from human serum.
journal, February 1992

Purification and characterization of a UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase from Ehrlich ascites tumor cells.
journal, May 1986

The isolation and sequence of the gene encoding T8: A molecule defining functional classes of T lymphocytes
journal, February 1985

The cloning and expression of a human α-1,3 fucosyltransferase capable of forming the E-selectin ligand
journal, August 1992

Capitalizing on Carbohydrates
journal, February 1990

Co-transformation of Lec1 CHO cells with N-acetylgucosaminyltransferase 1 activity and a selectable marker
journal, March 1990

Co-purification of the Lewis blood group N-acetylglucosaminide alpha 1 goes to 4 fucosyltransferase and an N-acetylglucosaminide alpha 1 goes to 3 fucosyltransferase from human milk.
journal, October 1981

Protective effects of sialylated oligosaccharides in immune complex-induced acute lung injury.
journal, August 1993

Biosynthesis of terminal Gal alpha 1—-3Gal beta 1—-4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1—-3-galactosyltransferase from calf thymus.
journal, October 1985

Acceptor specificity and tissue distribution of three human alpha-3-fucosyltransferases
journal, July 1990

A Cloned Human DNA Restriction Fragment Determines Expression of a GDP-L-fucose:β-D-Galactoside 2-α-L-fucosytransferase in Transfected Cells
journal, July 1989

Purification to homogeneity of H blood group beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
journal, June 1980

Bovine galactosyltransferase: identification of a clone by direct immunological screening of a cDNA expression library.
journal, March 1986

Molecular Cloning and Expression of Two Types of Rabbit β-Galactoside α1,2-Fucosyltransferase
journal, April 1995

Gene transfer, expression, and molecular cloning of the human transferrin receptor gene
journal, May 1984

Enzyme-catalyzed synthesis of carbohydrates
journal, January 1989

Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland.
journal, June 1980

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor
journal, July 1978

A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase.
journal, August 1990

Gene transfer and molecular cloning of the human NGF receptor
journal, April 1986

Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes.
journal, December 1992

Stable Expression of Blood Group H Determinants and GDP-L-fucose: β-D-galactoside 2-α-L-Fucosyltransferase in Mouse Cells After Transfection with Human DNA
journal, February 1989

A new technique for the assay of infectivity of human adenovirus 5 DNA
journal, April 1973

Purification of theN-acetylglucosaminide ?(1?3/4) fucosyltransferase of human milk
journal, January 1989

Purification of the secretor-type beta-galactoside alpha 1----2-fucosyltransferase from human serum.
journal, February 1992

DNA-mediated transformation of N-acetylglucosaminyltransferase I activity into an enzyme deficient cell line
journal, March 1989

Primary structure of beta-galactoside alpha 2,6-sialyltransferase. Conversion of membrane-bound enzyme to soluble forms by cleavage of the NH2-terminal signal anchor.
journal, December 1987

Protective effects of oligosaccharides in P-selectin-dependent lung injury
journal, July 1993

Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen.
journal, September 1990

Isolation of a cDNA encoding a murine UDPgalactose:beta-D-galactosyl- 1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase: expression cloning by gene transfer.
journal, November 1989

Purification of a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase and a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase to homogeneity from rat liver.
journal, November 1982

Human α-1,3 Fucosyltransferase (FucT-VI) Gene Is Located at Only 13 kb 3′ to the Lewis Type Fucosyltransferase (FucT-III) Gene on Chromosome 19
journal, January 1993

Sequence and Expression of a Candidate for the Human Secretor Blood Group α(1,2)Fucosyltransferase Gene (FUT2)
journal, March 1995

Isolation of a cDNA coding for human galactosyltransferase
journal, August 1986

Evidence for two distinct α(1,2)-fucosyltransferase genes differentially expressed throughout the rat colon
journal, June 1994

Purification and Characterization of Secretory-Type GDP-L-Fucose: β-D-Galactoside 2-α-L-Fucosyltransferase from Human Gastric Mucosa1
journal, September 1995

Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes.
journal, May 1994

Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities.
journal, February 1992