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Title: Reduction of diffusional defocusing in hydrodynamically focused flows

Abstract

An analyte fluid stream with first molecules having relatively low molecular weight and a corresponding high coefficient of diffusion has reduced diffusional defocusing out of an analyte fluid stream. The analyte fluid stream of first molecules is associated with second molecules of relatively high molecular weight having a relatively low coefficient of diffusion and a binding constant effective to associate with the first molecules. A focused analyte fluid stream is maintained since the combined molecular weight of the associated first and second molecules is effective to minimize diffusion of the first molecules out of the analyte fluid stream.

Inventors:
 [1];  [2];  [3];  [4];  [5]
  1. (Lawrenceville, NJ)
  2. (Charlottesville, VA)
  3. (Jemez Springs, NM)
  4. (Los Alamos, NM)
  5. (Middle Island, NY)
Issue Date:
Research Org.:
Los Alamos National Laboratory (LANL), Los Alamos, NM
OSTI Identifier:
871807
Patent Number(s):
5799682
Assignee:
Regents of University of California (Los Alamos, NM) LANL
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
reduction; diffusional; defocusing; hydrodynamically; focused; flows; analyte; fluid; stream; molecules; relatively; molecular; weight; corresponding; coefficient; diffusion; reduced; associated; binding; constant; effective; associate; maintained; combined; minimize; fluid stream; molecular weight; diffusional defocusing; /137/

Citation Formats

Affleck, Rhett L., Demas, James N., Goodwin, Peter M., Keller, Richard, and Wu, Ming. Reduction of diffusional defocusing in hydrodynamically focused flows. United States: N. p., 1998. Web.
Affleck, Rhett L., Demas, James N., Goodwin, Peter M., Keller, Richard, & Wu, Ming. Reduction of diffusional defocusing in hydrodynamically focused flows. United States.
Affleck, Rhett L., Demas, James N., Goodwin, Peter M., Keller, Richard, and Wu, Ming. Thu . "Reduction of diffusional defocusing in hydrodynamically focused flows". United States. https://www.osti.gov/servlets/purl/871807.
@article{osti_871807,
title = {Reduction of diffusional defocusing in hydrodynamically focused flows},
author = {Affleck, Rhett L. and Demas, James N. and Goodwin, Peter M. and Keller, Richard and Wu, Ming},
abstractNote = {An analyte fluid stream with first molecules having relatively low molecular weight and a corresponding high coefficient of diffusion has reduced diffusional defocusing out of an analyte fluid stream. The analyte fluid stream of first molecules is associated with second molecules of relatively high molecular weight having a relatively low coefficient of diffusion and a binding constant effective to associate with the first molecules. A focused analyte fluid stream is maintained since the combined molecular weight of the associated first and second molecules is effective to minimize diffusion of the first molecules out of the analyte fluid stream.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {1}
}

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