Title: Biomarkers of cell senescence

Abstract

The present invention provides a biomarker system for the in vivo and in vitro assessment of cell senescence. In the method of the present invention, .beta.-galactosidase activity is utilized as a means by which cell senescence may be assessed either in vitro cell cultures or in vivo.

Inventors:

Dimri, Goberdhan P ^[1]; Campisi, Judith ^[2]; Peacocke, Monica ^[3]

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1. Simli U.P., IN
2. Berkeley, CA
3. Newton, MA

Issue Date:

1998-01-01

Research Org.:

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

OSTI Identifier:

871786

Patent Number(s):

5795728

Assignee:

Regents of University of California (Oakland, CA)

Patent Classifications (CPCs):

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/5005 - {involving human or animal cells

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q1/54 - involving glucose or galactose

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DOE Contract Number:  

AC03-76SF00098

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

biomarkers; cell; senescence; provides; biomarker; vivo; vitro; assessment; method; beta; -galactosidase; activity; utilized; means; assessed; cultures; cell senescence; cell culture; cell cultures; vitro assessment; vitro cell; -galactosidase activity; /435/436/