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Title: Biomarkers of cell senescence

Abstract

The present invention provides a biomarker system for the in vivo and in vitro assessment of cell senescence. In the method of the present invention, .beta.-galactosidase activity is utilized as a means by which cell senescence may be assessed either in vitro cell cultures or in vivo.

Inventors:
 [1];  [2];  [3]
  1. Simli U.P., IN
  2. Berkeley, CA
  3. Newton, MA
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
OSTI Identifier:
871786
Patent Number(s):
5795728
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
biomarkers; cell; senescence; provides; biomarker; vivo; vitro; assessment; method; beta; -galactosidase; activity; utilized; means; assessed; cultures; cell senescence; cell culture; cell cultures; vitro assessment; vitro cell; -galactosidase activity; /435/436/

Citation Formats

Dimri, Goberdhan P, Campisi, Judith, and Peacocke, Monica. Biomarkers of cell senescence. United States: N. p., 1998. Web.
Dimri, Goberdhan P, Campisi, Judith, & Peacocke, Monica. Biomarkers of cell senescence. United States.
Dimri, Goberdhan P, Campisi, Judith, and Peacocke, Monica. Thu . "Biomarkers of cell senescence". United States. https://www.osti.gov/servlets/purl/871786.
@article{osti_871786,
title = {Biomarkers of cell senescence},
author = {Dimri, Goberdhan P and Campisi, Judith and Peacocke, Monica},
abstractNote = {The present invention provides a biomarker system for the in vivo and in vitro assessment of cell senescence. In the method of the present invention, .beta.-galactosidase activity is utilized as a means by which cell senescence may be assessed either in vitro cell cultures or in vivo.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {1}
}

Works referenced in this record:

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The limited in vitro lifetime of human diploid cell strains
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Loss of a critical neutral protease in ageing WI-38 cells
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Cellular senescence: A reflection of normal growth control, differentiation, or aging?
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The serial cultivation of human diploid cell strains
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Senescence-induced alteration in cell surface carbohydrates correlated using proton NMR spectroscopy and a lectin-based affinity-binding assay
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Replicative senescence: the human fibroblast comes of age
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Immortal phenotype of the HeLa variant D98 is recessive in hybrids formed with normal human fibroblasts
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β-Galactosidase Activity in Transfected Ltk- Cells is Differentially Regulated in Monolayer and in Spheroid Cultures
journal, July 1993


Tumor suppression by chromosome 11 is not due to cellular senescence
journal, January 1991


Cellular aging and senescence
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