Computer-aided visualization and analysis system for sequence evaluation
Abstract
A computer system for analyzing nucleic acid sequences is provided. The computer system is used to perform multiple methods for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acid probes. The results of individual experiments are improved by processing nucleic acid sequences together. Comparative analysis of multiple experiments is also provided by displaying reference sequences in one area and sample sequences in another area on a display device.
- Inventors:
-
- 3199 Waverly St., Palo Alto, CA 94306
- Issue Date:
- Research Org.:
- Affymetrix, Inc. (Santa Clara, CA)
- OSTI Identifier:
- 871785
- Patent Number(s):
- 5795716
- Application Number:
- 08/327,525
- Assignee:
- Chee, Mark S. (3199 Waverly St., Palo Alto, CA 94306)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
- DOE Contract Number:
- FG03-92ER81275
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- computer-aided; visualization; analysis; sequence; evaluation; computer; analyzing; nucleic; acid; sequences; provided; perform; multiple; methods; determining; bases; fluorescence; intensities; hybridized; probes; results; individual; experiments; improved; processing; comparative; displaying; reference; sample; display; device; comparative analysis; reference sequence; acid probes; acid sequence; nucleic acid; acid sequences; acid probe; display device; sequence evaluation; sample sequences; analyzing nucleic; processing nucleic; multiple experiments; multiple methods; computer-aided visualization; reference sequences; perform multiple; fluorescence intensities; form multiple; displaying reference; individual experiments; hybridized nucleic; /435/382/999/
Citation Formats
Chee, Mark S. Computer-aided visualization and analysis system for sequence evaluation. United States: N. p., 1998.
Web.
Chee, Mark S. Computer-aided visualization and analysis system for sequence evaluation. United States.
Chee, Mark S. Tue .
"Computer-aided visualization and analysis system for sequence evaluation". United States. https://www.osti.gov/servlets/purl/871785.
@article{osti_871785,
title = {Computer-aided visualization and analysis system for sequence evaluation},
author = {Chee, Mark S},
abstractNote = {A computer system for analyzing nucleic acid sequences is provided. The computer system is used to perform multiple methods for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acid probes. The results of individual experiments are improved by processing nucleic acid sequences together. Comparative analysis of multiple experiments is also provided by displaying reference sequences in one area and sample sequences in another area on a display device.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {8}
}
Works referenced in this record:
An Algorithm for the DNA Sequence Generation from k-Tuple Word Contents of the Minimal Number of Random Fragments
journal, April 1991
- Drmanac, R.; Labat, I.; Crkvenjakov, R.
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journal, November 1991
- Strezoska, Z.; Paunesku, T.; Radosavljevic, D.
- Proceedings of the National Academy of Sciences, Vol. 88, Issue 22
DNA sequence determination by hybridization: a strategy for efficient large-scale sequencing
journal, June 1993
- Drmanac, R.; Drmanac, S.; Strezoska, Z.
- Science, Vol. 260, Issue 5114
Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: Evaluation using experimental models
journal, August 1992
- Southern, E. M.; Maskos, U.; Elder, J. K.
- Genomics, Vol. 13, Issue 4, p. 1008-1017