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Title: Resonant-cavity apparatus for cytometry or particle analysis

Abstract

A resonant-cavity apparatus for cytometry or particle analysis. The apparatus comprises a resonant optical cavity having an analysis region within the cavity for containing one or more biological cells or dielectric particles to be analyzed. In the presence of a cell or particle, a light beam in the form of spontaneous emission or lasing is generated within the resonant optical cavity and is encoded with information about the cell or particle. An analysis means including a spectrometer and/or a pulse-height analyzer is provided within the apparatus for recovery of the information from the light beam to determine a size, shape, identification or other characteristics about the cells or particles being analyzed. The recovered information can be grouped in a multi-dimensional coordinate space for identification of particular types of cells or particles. In some embodiments of the apparatus, the resonant optical cavity can be formed, at least in part, from a vertical-cavity surface-emitting laser. The apparatus and method are particularly suited to the analysis of biological cells, including blood cells, and can further include processing means for manipulating, sorting, or eradicating cells after analysis thereof.

Inventors:
 [1]
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  1. Albuquerque, NM
Issue Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
OSTI Identifier:
871776
Patent Number(s):
5793485
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G - PHYSICS G02 - OPTICS G02B - OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
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DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
resonant-cavity; apparatus; cytometry; particle; analysis; comprises; resonant; optical; cavity; region; containing; biological; cells; dielectric; particles; analyzed; presence; cell; light; beam; form; spontaneous; emission; lasing; generated; encoded; information; means; including; spectrometer; pulse-height; analyzer; provided; recovery; determine; size; shape; identification; characteristics; recovered; multi-dimensional; coordinate; space; particular; types; embodiments; formed; vertical-cavity; surface-emitting; laser; method; particularly; suited; blood; processing; manipulating; sorting; eradicating; cavity surface; analysis region; surface-emitting laser; resonant optical; vertical-cavity surface-emitting; means including; particularly suited; optical cavity; blood cells; apparatus comprises; light beam; biological cells; processing means; blood cell; apparatus comprise; particular type; particle analysis; spontaneous emission; emitting laser; height analyzer; resonant-cavity apparatus; biological cell; /356/

Citation Formats

Gourley, Paul L. Resonant-cavity apparatus for cytometry or particle analysis. United States: N. p., 1998. Web.
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Gourley, Paul L. Resonant-cavity apparatus for cytometry or particle analysis. United States.
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Gourley, Paul L. Thu . "Resonant-cavity apparatus for cytometry or particle analysis". United States. https://www.osti.gov/servlets/purl/871776.
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@article{osti_871776,
title = {Resonant-cavity apparatus for cytometry or particle analysis},
author = {Gourley, Paul L},
abstractNote = {A resonant-cavity apparatus for cytometry or particle analysis. The apparatus comprises a resonant optical cavity having an analysis region within the cavity for containing one or more biological cells or dielectric particles to be analyzed. In the presence of a cell or particle, a light beam in the form of spontaneous emission or lasing is generated within the resonant optical cavity and is encoded with information about the cell or particle. An analysis means including a spectrometer and/or a pulse-height analyzer is provided within the apparatus for recovery of the information from the light beam to determine a size, shape, identification or other characteristics about the cells or particles being analyzed. The recovered information can be grouped in a multi-dimensional coordinate space for identification of particular types of cells or particles. In some embodiments of the apparatus, the resonant optical cavity can be formed, at least in part, from a vertical-cavity surface-emitting laser. The apparatus and method are particularly suited to the analysis of biological cells, including blood cells, and can further include processing means for manipulating, sorting, or eradicating cells after analysis thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 1998},
month = {Thu Jan 01 00:00:00 EST 1998}
}
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Works referenced in this record:

Semiconductor microlasers: A new approach to cell–structure analysis
journal, August 1996

Intracavity spectroscopy in vertical cavity surface‐emitting lasers for micro‐optical‐mechanical systems
journal, September 1996

Vertical cavity surface-emitting laser scanning cytometer for high-speed analysis of cells
conference, April 1996

Lasers and fiber optics in medicine
conference, June 1993

Surface-emitting semiconductor laser spectroscopy and microscopy for characterizing normal and sickled red blood cells
conference, April 1995

The Blood
book, January 1983

Optical trapping and manipulation of single cells using infrared laser beams
journal, December 1987

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