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Title: Near-infrared noninvasive spectroscopic determination of pH

Abstract

Methods and apparatus for, preferably, determining noninvasively and in vitro pH in a human. The non-invasive method includes the steps of: generating light at three or more different wavelengths in the range of 1000 nm to 2500 nm; irradiating blood containing tissue; measuring the intensities of the wavelengths emerging from the blood containing tissue to obtain a set of at least three spectral intensities v. wavelengths; and determining the unknown values of pH. The determination of pH is made by using measured intensities at wavelengths that exhibit change in absorbance due to histidine titration. Histidine absorbance changes are due to titration by hydrogen ions. The determination of the unknown pH values is performed by at least one multivariate algorithm using two or more variables and at least one calibration model. The determined pH values are within the physiological ranges observed in blood containing tissue. The apparatus includes a tissue positioning device, a source, at least one detector, electronics, a microprocessor, memory, and apparatus for indicating the determined values.

Inventors:
 [1];  [2]
  1. P.O. Box 1083, Cedar Crest, NM 87008
  2. 1415 Calle del Ranchero NE, Albuquerque, NM 87106
Issue Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
OSTI Identifier:
871767
Patent Number(s):
5792050
Application Number:
08/615,762
Assignee:
Alam, Mary K. (P.O. Box 1083, Cedar Crest, NM 87008);Robinson, Mark R. (1415 Calle del Ranchero NE, Albuquerque, NM 87106)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
near-infrared; noninvasive; spectroscopic; determination; ph; methods; apparatus; preferably; determining; noninvasively; vitro; human; non-invasive; method; steps; generating; light; wavelengths; range; 1000; nm; 2500; irradiating; blood; containing; tissue; measuring; intensities; emerging; obtain; set; spectral; values; measured; exhibit; change; absorbance; due; histidine; titration; changes; hydrogen; performed; multivariate; algorithm; variables; calibration; model; determined; physiological; ranges; observed; positioning; device; source; detector; electronics; microprocessor; memory; indicating; blood containing; containing tissue; ph value; ph values; positioning device; multivariate algorithm; generating light; non-invasive method; determining noninvasively; determined values; calibration mode; /600/356/

Citation Formats

Alam, Mary K, and Robinson, Mark R. Near-infrared noninvasive spectroscopic determination of pH. United States: N. p., 1998. Web.
Alam, Mary K, & Robinson, Mark R. Near-infrared noninvasive spectroscopic determination of pH. United States.
Alam, Mary K, and Robinson, Mark R. Tue . "Near-infrared noninvasive spectroscopic determination of pH". United States. https://www.osti.gov/servlets/purl/871767.
@article{osti_871767,
title = {Near-infrared noninvasive spectroscopic determination of pH},
author = {Alam, Mary K and Robinson, Mark R},
abstractNote = {Methods and apparatus for, preferably, determining noninvasively and in vitro pH in a human. The non-invasive method includes the steps of: generating light at three or more different wavelengths in the range of 1000 nm to 2500 nm; irradiating blood containing tissue; measuring the intensities of the wavelengths emerging from the blood containing tissue to obtain a set of at least three spectral intensities v. wavelengths; and determining the unknown values of pH. The determination of pH is made by using measured intensities at wavelengths that exhibit change in absorbance due to histidine titration. Histidine absorbance changes are due to titration by hydrogen ions. The determination of the unknown pH values is performed by at least one multivariate algorithm using two or more variables and at least one calibration model. The determined pH values are within the physiological ranges observed in blood containing tissue. The apparatus includes a tissue positioning device, a source, at least one detector, electronics, a microprocessor, memory, and apparatus for indicating the determined values.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {8}
}

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