Isolation and characterization of Agouti: a diabetes/obesity related gene
Abstract
The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.
- Inventors:
-
- Knoxville, TN
- Issue Date:
- Research Org.:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- OSTI Identifier:
- 871757
- Patent Number(s):
- 5789651
- Assignee:
- Martin Marietta Energy Systems, Inc. (Oak Ridge, TN)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- isolation; characterization; agouti; diabetes; obesity; related; relates; cloning; expression; analogous; genes; transformed; transfected; transgenic; mice; provides; animal; model; study; tumors; testing; potential; therapeutic; agents; oligonucleotide; probes; detection; mutations; recombinant; production; product; antibodies; diagnostic; oligonucleotide probes; therapeutic agents; recombinant production; provides oligonucleotide; transgenic mice; therapeutic agent; animal model; analogous genes; potential therapeutic; obesity related; oligonucleotide probe; /800/435/999/
Citation Formats
Woychik, Richard P. Isolation and characterization of Agouti: a diabetes/obesity related gene. United States: N. p., 1998.
Web.
Woychik, Richard P. Isolation and characterization of Agouti: a diabetes/obesity related gene. United States.
Woychik, Richard P. Thu .
"Isolation and characterization of Agouti: a diabetes/obesity related gene". United States. https://www.osti.gov/servlets/purl/871757.
@article{osti_871757,
title = {Isolation and characterization of Agouti: a diabetes/obesity related gene},
author = {Woychik, Richard P},
abstractNote = {The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {1}
}
Works referenced in this record:
Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice
journal, May 1986
- Wolff, G. L.; Roberts, D. W.; Galbraith, D. B.
- Journal of Heredity, Vol. 77, Issue 3
Multiple pay contingencies: Strategic design of compensation
journal, October 1989
- Mahoney, Thomas A.
- Human Resource Management, Vol. 28, Issue 3
Molecular characterization of the mouse agouti locus
journal, December 1992
- Bultman, Scott J.; Michaud, Edward J.; Woychik, Richard P.
- Cell, Vol. 71, Issue 7