Isolation and characterization of Agouti: a diabetes/obesity related gene

Woychik, Richard P

Title: Isolation and characterization of Agouti: a diabetes/obesity related gene

Abstract

The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.

Inventors:

Woychik, Richard P ^[1]

Knoxville, TN

Issue Date:: 1998-01-01

Research Org.:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

OSTI Identifier:: 871757

Patent Number(s):: 5789651

Assignee:: Martin Marietta Energy Systems, Inc. (Oak Ridge, TN)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

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A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY
A01K2227/105 - Murine
A01K2217/05 - Animals comprising random inserted nucleic acids

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N15/8509 - {for producing genetically modified animals, e.g. transgenic}

A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY
A01K67/0275 - {Genetically modified vertebrates, e.g. transgenic}

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N2830/85 - mammalian

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/47 - from mammals

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N2830/008 - cell type or tissue specific enhancer/promoter combination

A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY
A01K2267/0306 - Animal model for genetic diseases
A01K2267/03 - Animal model, e.g. for test or diseases
A01K2267/0362 - Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes

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Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: isolation; characterization; agouti; diabetes; obesity; related; relates; cloning; expression; analogous; genes; transformed; transfected; transgenic; mice; provides; animal; model; study; tumors; testing; potential; therapeutic; agents; oligonucleotide; probes; detection; mutations; recombinant; production; product; antibodies; diagnostic; oligonucleotide probes; therapeutic agents; recombinant production; provides oligonucleotide; transgenic mice; therapeutic agent; animal model; analogous genes; potential therapeutic; obesity related; oligonucleotide probe; /800/435/999/

Citation Formats


                    Woychik, Richard P. Isolation and characterization of Agouti: a diabetes/obesity related gene.  United States: N. p., 1998. 
        Web.

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                    Woychik, Richard P. Isolation and characterization of Agouti: a diabetes/obesity related gene.  United States.

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                    Woychik, Richard P. Thu .  
        "Isolation and characterization of Agouti: a diabetes/obesity related gene".  United States.  https://www.osti.gov/servlets/purl/871757.

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@article{osti_871757,

  title        = {Isolation and characterization of Agouti: a diabetes/obesity related gene},

  author       = {Woychik, Richard P},

  abstractNote = {The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1998},

  month        = {1}

}

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Works referenced in this record:

Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice
journal, May 1986

Wolff, G. L.; Roberts, D. W.; Galbraith, D. B.
Journal of Heredity, Vol. 77, Issue 3
https://doi.org/10.1093/oxfordjournals.jhered.a110206

Multiple pay contingencies: Strategic design of compensation
journal, October 1989

Mahoney, Thomas A.
Human Resource Management, Vol. 28, Issue 3
https://doi.org/10.1002/hrm.3930280304

Molecular characterization of the mouse agouti locus
journal, December 1992

Bultman, Scott J.; Michaud, Edward J.; Woychik, Richard P.
Cell, Vol. 71, Issue 7
https://doi.org/10.1016/S0092-8674(05)80067-4

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Similar Records

Title: Isolation and characterization of Agouti: a diabetes/obesity related gene

Abstract

Citation Formats

Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice journal, May 1986

Multiple pay contingencies: Strategic design of compensation journal, October 1989

Molecular characterization of the mouse agouti locus journal, December 1992

Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice
journal, May 1986

Multiple pay contingencies: Strategic design of compensation
journal, October 1989

Molecular characterization of the mouse agouti locus
journal, December 1992