Method for identifying and quantifying nucleic acid sequence aberrations

Title: Method for identifying and quantifying nucleic acid sequence aberrations

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Abstract

A method for detecting nucleic acid sequence aberrations by detecting nucleic acid sequences having both a first and a second nucleic acid sequence type, the presence of the first and second sequence type on the same nucleic acid sequence indicating the presence of a nucleic acid sequence aberration. The method uses a first hybridization probe which includes a nucleic acid sequence that is complementary to a first sequence type and a first complexing agent capable of attaching to a second complexing agent and a second hybridization probe which includes a nucleic acid sequence that selectively hybridizes to the second nucleic acid sequence type over the first sequence type and includes a detectable marker for detecting the second hybridization probe.

Inventors:

Lucas, Joe N. ^[1]; Straume, Tore ^[2]; Bogen, Kenneth T. ^[3]

(San Ramon, CA)
(Tracy, CA)
(Walnut Creek, CA)

Issue Date:: 1998-01-01

Research Org.:: Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

OSTI Identifier:: 871727

Patent Number(s):: 5783387

Assignee:: Regents of University of California (Oakland, CA) LLNL

DOE Contract Number:: W-7405-ENG-48

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: method; identifying; quantifying; nucleic; acid; sequence; aberrations; detecting; sequences; type; presence; indicating; aberration; hybridization; probe; complementary; complexing; agent; capable; attaching; selectively; hybridizes; detectable; marker; sequence aberration; detecting nucleic; detectable marker; sequence aberrations; sequence type; acid sequence; nucleic acid; acid sequences; complexing agent; hybridization probe; agent capable; sequence indicating; /435/999/

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                    Lucas, Joe N., Straume, Tore, and Bogen, Kenneth T. Method for identifying and quantifying nucleic acid sequence aberrations.  United States: N. p., 1998. 
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                    Lucas, Joe N., Straume, Tore, & Bogen, Kenneth T. Method for identifying and quantifying nucleic acid sequence aberrations.  United States.

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                    Lucas, Joe N., Straume, Tore, and Bogen, Kenneth T. Thu .  
        "Method for identifying and quantifying nucleic acid sequence aberrations".  United States.  https://www.osti.gov/servlets/purl/871727.

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@article{osti_871727,

  title        = {Method for identifying and quantifying nucleic acid sequence aberrations},

  author       = {Lucas, Joe N. and Straume, Tore and Bogen, Kenneth T.},

  abstractNote = {A method for detecting nucleic acid sequence aberrations by detecting nucleic acid sequences having both a first and a second nucleic acid sequence type, the presence of the first and second sequence type on the same nucleic acid sequence indicating the presence of a nucleic acid sequence aberration. The method uses a first hybridization probe which includes a nucleic acid sequence that is complementary to a first sequence type and a first complexing agent capable of attaching to a second complexing agent and a second hybridization probe which includes a nucleic acid sequence that selectively hybridizes to the second nucleic acid sequence type over the first sequence type and includes a detectable marker for detecting the second hybridization probe.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {1998},

  month        = {1}

}

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