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Title: Method for identifying and quantifying nucleic acid sequence aberrations

Abstract

A method for detecting nucleic acid sequence aberrations by detecting nucleic acid sequences having both a first and a second nucleic acid sequence type, the presence of the first and second sequence type on the same nucleic acid sequence indicating the presence of a nucleic acid sequence aberration. The method uses a first hybridization probe which includes a nucleic acid sequence that is complementary to a first sequence type and a first complexing agent capable of attaching to a second complexing agent and a second hybridization probe which includes a nucleic acid sequence that selectively hybridizes to the second nucleic acid sequence type over the first sequence type and includes a detectable marker for detecting the second hybridization probe.

Inventors:
 [1];  [2];  [3]
  1. (San Ramon, CA)
  2. (Tracy, CA)
  3. (Walnut Creek, CA)
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
871727
Patent Number(s):
5783387
Assignee:
Regents of University of California (Oakland, CA) LLNL
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; identifying; quantifying; nucleic; acid; sequence; aberrations; detecting; sequences; type; presence; indicating; aberration; hybridization; probe; complementary; complexing; agent; capable; attaching; selectively; hybridizes; detectable; marker; sequence aberration; detecting nucleic; detectable marker; sequence aberrations; sequence type; acid sequence; nucleic acid; acid sequences; complexing agent; hybridization probe; agent capable; sequence indicating; /435/999/

Citation Formats

Lucas, Joe N., Straume, Tore, and Bogen, Kenneth T. Method for identifying and quantifying nucleic acid sequence aberrations. United States: N. p., 1998. Web.
Lucas, Joe N., Straume, Tore, & Bogen, Kenneth T. Method for identifying and quantifying nucleic acid sequence aberrations. United States.
Lucas, Joe N., Straume, Tore, and Bogen, Kenneth T. Thu . "Method for identifying and quantifying nucleic acid sequence aberrations". United States. https://www.osti.gov/servlets/purl/871727.
@article{osti_871727,
title = {Method for identifying and quantifying nucleic acid sequence aberrations},
author = {Lucas, Joe N. and Straume, Tore and Bogen, Kenneth T.},
abstractNote = {A method for detecting nucleic acid sequence aberrations by detecting nucleic acid sequences having both a first and a second nucleic acid sequence type, the presence of the first and second sequence type on the same nucleic acid sequence indicating the presence of a nucleic acid sequence aberration. The method uses a first hybridization probe which includes a nucleic acid sequence that is complementary to a first sequence type and a first complexing agent capable of attaching to a second complexing agent and a second hybridization probe which includes a nucleic acid sequence that selectively hybridizes to the second nucleic acid sequence type over the first sequence type and includes a detectable marker for detecting the second hybridization probe.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {1}
}

Patent:

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