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Title: Triggered pore-forming agents


An inactive pore-forming agent which is activated to lytic function by a condition such as pH, light, heat, reducing potential, or metal ion concentration, or substance such as a protease, at the surface of a cell.

 [1];  [2];  [3];  [4];  [5]
  1. Grafton, MA
  2. Auburn, MA
  3. Worcester, MA
  4. Nashville, TN
  5. Shrewsbury, MA
Issue Date:
Research Org.:
Worcester Foundation
OSTI Identifier:
Patent Number(s):
Worcester Foundation for Experimental Biology (Shrewsbury, MA)
Patent Classifications (CPCs):
DOE Contract Number:  
Resource Type:
Country of Publication:
United States
triggered; pore-forming; agents; inactive; agent; activated; lytic; function; condition; ph; light; heat; reducing; potential; metal; concentration; substance; protease; surface; cell; pore-forming agents; pore-forming agent; forming agent; /530/

Citation Formats

Bayley, Hagan, Walker, Barbara J, Chang, Chung-yu, Niblack, Brett, and Panchal, Rekha. Triggered pore-forming agents. United States: N. p., 1998. Web.
Bayley, Hagan, Walker, Barbara J, Chang, Chung-yu, Niblack, Brett, & Panchal, Rekha. Triggered pore-forming agents. United States.
Bayley, Hagan, Walker, Barbara J, Chang, Chung-yu, Niblack, Brett, and Panchal, Rekha. Tue . "Triggered pore-forming agents". United States.
title = {Triggered pore-forming agents},
author = {Bayley, Hagan and Walker, Barbara J and Chang, Chung-yu and Niblack, Brett and Panchal, Rekha},
abstractNote = {An inactive pore-forming agent which is activated to lytic function by a condition such as pH, light, heat, reducing potential, or metal ion concentration, or substance such as a protease, at the surface of a cell.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {7}

Works referenced in this record:

Supramolecular surfactants: Amphiphilic polymers designed to disrupt lipid membranes
journal, March 1989

Self-assembling biomolecular materials in mediaine
journal, October 1994

Subunit stoichiometry of staphylococcal alpha-hemolysin in crystals and on membranes: a heptameric transmembrane pore.
journal, December 1994

journal, December 1986

The Activation of Human Type IV Collagenase Proenzyme
journal, January 1989

Photocleavable Nitrobenzyl-Protein Conjugates
journal, June 1994

Site-specific incorporation of novel backbone structures into proteins
journal, January 1992

Channels With Single Transmembrane Segments
journal, February 1994

Photoactivation of toxin conjugates
journal, March 1992

Genetically Engineered Pores as Metal Ion Biosensors
journal, January 1993

Restoration of pore-forming activity in staphylococcal α-hemolysin by targeted covalent modification
journal, January 1995

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
journal, January 1991

DNA-like double helix formed by peptide nucleic acid
journal, April 1994

Biochemical and Cytotoxic Properties of Conjugates of Transferrin with Equinatoxin II, a Cytolysin from a Sea Anemone
journal, March 1995

Triggeps and switches in a self-assembling pore-forming portein
journal, October 1994

Genetically-Engineered Protease-Activated Triggers in a Pore-Forming Protein
journal, January 1993

Photoactivatable drugs
journal, April 1987

A new immunotoxin built by linking a hemolytic toxin to a monoclonal antibody specific for immature T lymphocytes
journal, October 1988

Photocleavable Biotinylated Ligands for Affinity Chromatography
journal, May 1994

Secondary structure and assembly mechanism of an oligomeric channel protein
journal, April 1985

A general method for site-specific incorporation of unnatural amino acids into proteins
journal, April 1989

Assembly of the oligomeric membrane pore formed by Staphylococcal alpha-hemolysin examined by truncation mutagenesis.
journal, October 1992

Surface labeling of key residues during assembly of the transmembrane pore formed by staphylococcal α-hemolysin
journal, December 1994

Molecular design gets into a hole
journal, February 1992

A carcinoembryonic antigen-directed immunotoxin built by linking a monoclonal antibody to a hemolytic toxin
journal, May 1989

A photogenerated pore-forming protein
journal, June 1995

A Pore-forming protein with a protease-activated trigger
journal, January 1994

Cyclin-dependent kinases: regulators of the cell cycle and more
journal, December 1994

Homomeric assemblies of NMDAR1 splice variants are sensitive to ethanol
journal, April 1993

Controlling Cell Chemistry with Caged Compounds
journal, October 1993

Novel Photocleavable Protein Crosslinking Reagents and Their use in the Preparation of Antibody-Toxin Conjugates
journal, September 1985

Controlling Life's Gateway
journal, September 1994

Theoretical models of the ion channel structure of amyloid beta-protein
journal, December 1994

Functional complementation of staphylococcal alpha-hemolysin fragments. Overlaps, nicks, and gaps in the glycine-rich loop.
journal, March 1993

Primary sequence of the alpha-toxin gene from Staphylococcus aureus wood 46.
journal, January 1984

Halothane acts on many potassium channels, including a minimal potassium channel
journal, October 1993

Extending the chemistry of enzymes and abzymes
journal, January 1991

PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules
journal, October 1993

Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
journal, December 1991

An intermediate in the assembly of a pore-forming protein trapped with a genetically-engineered switch
journal, February 1995

Synthesis of proteins by native chemical ligation
journal, November 1994

Photocleavable biotin derivatives: a versatile approach for the isolation of biomolecules.
journal, August 1995

Tumor targeting: Activation of prodrugs by enzyme-monoclonal antibody conjugates
journal, June 1994

A pore-forming protein with a metal-actuated switch
journal, January 1994