Title: Triggered pore-forming agents

Abstract

An inactive pore-forming agent which is activated to lytic function by a condition such as pH, light, heat, reducing potential, or metal ion concentration, or substance such as a protease, at the surface of a cell.

Inventors:

Bayley, Hagan ^[1]; Walker, Barbara J ^[2]; Chang, Chung-yu ^[3]; Niblack, Brett ^[4]; Panchal, Rekha ^[5]

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+ Show Inventor Affiliations

1. Grafton, MA
2. Auburn, MA
3. Worcester, MA
4. Nashville, TN
5. Shrewsbury, MA

Issue Date:

1998-07-07

Research Org.:

Worcester Foundation

OSTI Identifier:

871686

Patent Number(s):

5777078

Assignee:

Worcester Foundation for Experimental Biology (Shrewsbury, MA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K38/00 - Medicinal preparations containing peptides
A61K41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation {
A61K47/585 - {Ion exchange resins, e.g. polystyrene sulfonic acid resin}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K14/31 - from Staphylococcus
C07K16/18 - against material from animals or humans
C07K2319/00 - Fusion polypeptide
C07K2319/50 - containing protease site
C07K2319/55 - containing a fusion with a toxin, e.g. diphteria toxin

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N15/62 - DNA sequences coding for fusion proteins

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/5008 - {for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics}
G01N33/5011 - {for testing antineoplastic activity}
G01N33/5014 - {for testing toxicity}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S530/82 - Proteins from microorganisms
Y10S530/825 - Bacteria

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DOE Contract Number:  

FG02-90ER20018

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

triggered; pore-forming; agents; inactive; agent; activated; lytic; function; condition; ph; light; heat; reducing; potential; metal; concentration; substance; protease; surface; cell; pore-forming agents; pore-forming agent; forming agent; /530/